Recombinant Human Transforming Growth Factor, Beta 3

• Cat.No.: TGFB3-349H

Specification

• Cat. No.: TGFB3-349H
• Description: Transforming growth factor-beta 3 (TGF-beta 3) is a member of the TGF beta family of growth factors. It is involved in oxygen-dependent differentiation processes during placental development and pregnancy disorders. It also play an important role in wound repair and scarring.
• Source: Sf21 Insect Cells.
• Molecular Weight: The predicted molecular weight of Recombinant Human TGF-β3 is Mr 25 kDa.
• State Of Matter: Lyophilized.
• Purity: >97% by SDS Page and analyzed by silver stain.
• Endotoxin: <1.0 EU/µg as determined by the LAL method.
• Formulation: This recombinant protein was lyophilized from a 0.2 μm filtered solution in 40% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA).
• Biological Activity: The biological activity of Human TGF-β3 was determined by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 for this effect is typically 0.03 - 0.08 ng/ml.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Information

• Gene Name: TGFB3 transforming growth factor, beta 3 [ Homo sapiens ]
• Synonyms: Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3; transforming growth factor, beta 3
• Gene ID: 7043
• mRNA Refseq: NM_003239
• Protein Refseq: NP_003230
• MIM: 190230
• UniProt ID: P10600
• Chromosome Location: 14q24
• Pathway: Cell cycle; Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Hypertrophic cardiomyopathy (HCM); MAPK signaling pathway; Pancreatic cancer;Pathways in cancer; Renal cell carcinoma; TGF-beta signaling pathway
• Function: Growth factor activity; Identical protein binding; Protein heterodimerization activity; Transforming growth factor beta binding; Type I transforming growth factor beta receptor binding; Type II transforming growth factor beta receptor binding