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Recombinant Human YARS, His-tagged

Cat.No. : YARS-31446TH
Product Overview : Recombinant fragment, corresponding to amino acids 3-528 of Human Tyrosyl tRNA synthetase with an N-terminal His Tag, approximately 62kDa
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Description : Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine.
Conjugation : HIS
Source : E. coli
Form : Lyophilised:reconstitution with 135 μl distilled water.
Storage buffer : Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium hydrogen phosphate, 10mM Sodium chloride, pH 4.5
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : DAPSPEEKLHLITRNLQEVLGEEKL KEILKERELKIYWGT ATTGKPHVAYFVPMSKIADFLKAGC EVTILFADLHAYL DNMKAPWELLELRVSYYENVIKAML ESIGVPLEKLKFI KGTDYQLSKEYTLDVYRLSSVVTQH DSKKAGAEVVKQVEH PLLSGLLYPGLQALDEEYLKVDAQF GGIDQRKIFTFAE KYLPALGYSKRVHLMNPMVPGLTGS KMSSSEEESKIDL LDRKEDVKKKLKKAFCEPGNVENNG VLSFIKHVLFPLKSEFVILRDEKWG GNKTYTAYVDLEKDFAAEVVHPGDL KNS VEVALNKLLDPIREKFNTPALKKLA SAAYPDPSKQKPM AKGPAKNSEPEEVIPSRLDIRVGKI ITVEKHPDADSLY VEKIDVGEAEPRTVVSGLVQFVPKE ELQDRLVVVLCNLKP QKMRGVESQGMLLCASIEGINRQVE PLDPPAGSAPGEH VFVKGYEKGQPDEELKPKKKVFEKL QADFKISEECIAQ WKQTNFMTKLGSISCKSLKGGNIS
Sequence Similarities : Belongs to the class-I aminoacyl-tRNA synthetase family.Contains 1 tRNA-binding domain.
Gene Name : YARS tyrosyl-tRNA synthetase [ Homo sapiens ]
Official Symbol : YARS
Synonyms : YARS; tyrosyl-tRNA synthetase; tyrosyl-tRNA synthetase, cytoplasmic; tyrosine tRNA ligase 1; cytoplasmic; tyrRS; YRS; YTS;
Gene ID : 8565
mRNA Refseq : NM_003680
Protein Refseq : NP_003671
MIM : 603623
Uniprot ID : P54577
Chromosome Location : 1p35.1
Pathway : Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Cytosolic tRNA aminoacylation, organism-specific biosystem;
Function : ATP binding; interleukin-8 receptor binding; ligase activity; nucleotide binding; signal transducer activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is YARS protein involved in cancer progression? 09/27/2021

YARS protein can promote tumor growth and metastasis in certain types of cancer through its role in protein synthesis and cell signaling pathways.

Can YARS protein modification be a potential therapeutic strategy? 11/16/2019

Modifying YARS protein function through small molecules or gene therapy is being explored as a potential therapeutic strategy in disease contexts.

Are there any specific populations that may benefit from YARS protein-targeted therapies? 08/28/2019

Certain cancer subtypes and neurological disorder patients with YARS protein dysregulation may potentially benefit from targeted therapies, pending further research.

How does YARS protein contribute to neurological disorders? 04/25/2017

YARS protein dysfunction has been implicated in certain neurological disorders, such as Charcot-Marie-Tooth disease and peripheral neuropathy.

Can YARS protein be a potential therapeutic target for cancer treatment? 04/02/2016

Research suggests that targeting YARS protein may have therapeutic potential in certain cancer types, but further studies are needed to validate this approach.

Customer Reviews (3)

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Reviews
07/30/2020

    The manufacturer of the YARS protein plays a vital role in supporting my trials.

    07/07/2020

      the YARS protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.

      12/18/2017

        By using the YARS protein in my experiments, I am confident in obtaining accurate and dependable data.

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