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Recombinant Human YWHAE

Cat.No. : YWHAE-26003TH
Product Overview : Recombinant full-length human 14-3-3 epsilon with an N-terminal tag, 55 kDa.
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  • Gene Information
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Description : This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
Source : E. coli
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the 14-3-3 family.
Gene Name : YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide [ Homo sapiens ]
Official Symbol : YWHAE
Synonyms : YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; 14-3-3 protein epsilon; 14 3 3 epsilon; FLJ45465;
Gene ID : 7531
mRNA Refseq : NM_006761
Protein Refseq : NP_006752
MIM : 605066
Uniprot ID : P62258
Chromosome Location : 17p13.3
Pathway : Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function : enzyme binding; histone deacetylase binding; phosphoprotein binding; phosphoserine binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some clinical applications of studying YWHAE in cancer? 12/30/2021

YWHAE can serve as a potential biomarker for cancer diagnosis and prognosis.

How can YWHAE be used in predicting cancer patient outcomes? 10/08/2021

YWHAE levels and mutations can help predict patient responses to treatment and overall survival.

Are there targeted therapies based on YWHAE in cancer treatment? 02/13/2021

Targeted therapies that aim to inhibit YWHAE function are being explored as potential treatments for specific cancer types.

Can YWHAE be used for personalized medicine? 09/30/2017

YWHAE data may contribute to personalized treatment strategies for cancer patients based on their YWHAE status.

Is YWHAE a therapeutic target for psychiatric disorders? 07/16/2017

YWHAE is being studied as a potential therapeutic target for certain psychiatric disorders, but more research is needed.

Customer Reviews (3)

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Reviews
07/18/2021

    In protein electron microscopy structure analysis, the YWHAE protein demonstrates outstanding performance.

    06/25/2021

      Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.

      01/13/2021

        the YWHAE protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

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