"IL4" Related Products

Recombinant Human Interleukin 4

Cat. No.: IL4-59H
Product Overview: Recombinant Human Interleukin-4 produced inCHOis a single, non-glycosylated polypeptide chain containing 129 amino acids and having a molecular mass of 14 kDa, the glycosilation of IL-4 migrates as 18 kDa on SDS-PAGE. The IL-4 is purified by proprietary chromatographic techniques.
Description: IL4 is a pleiotropic cytokine produced by activated T cells. IL4 is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. IL4, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Source: Chinese Hamster Ovarian Cells.
Amino Acid Sequence: The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Pro-Gly-Gln-Thr.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: Lyophilized from a Phosphate- Buffered Saline (pH 7.4).
Solubility: It is recommended to reconstitute the lyophilized Interleukin-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Biological Activity: Measured in a cell proliferation assay using TF-1 cells. The ED50 for this effect is 0.05-0.2 ng/ml.
Storage: Lyophilized Interleukin-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution IL4 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: IL4 interleukin 4 [ Homo sapiens ]
Synonyms: IL4; interleukin 4; BSF1; IL-4; BCGF1; BCGF-1; MGC79402; B cell growth factor 1; B_cell stimulatory factor 1; lymphocyte stimulatory factor 1; Lymphocyte stimulatory factor 1; B-cell stimulatory factor 1; Pitrakinra; Binetrakin; BSF-1
Gene ID: 3565
mRNA Refseq: NM_000589
Protein Refseq: NP_000580
MIM: 147780
UniProt ID: P05112
Chromosome Location: 5q31.1
Pathway: T cell receptor signaling pathway; Jak-STAT signaling pathway; Fc epsilon RI signaling pathway; Cytokine-cytokine receptor interaction; Autoimmune thyroid disease; Allograft rejection; Asthma; Hematopoietic cell lineage
Function: cytokine activity; growth factor activity; protein binding; interleukin-4 receptor binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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