Recombinant Human Mitogen-activated protein kinase 1, His tagged
Cat.No. : | MAPK1-529H |
Product Overview : | Recombinant human MAPK1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Cat. No. : | MAPK1-529H |
Description : | MAPK1, also known as ERK(extracellular signal-regulated kinase), acts as an integration point for multiple biochemical signals, and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS |
Form : | Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol |
Molecular Weight : | 43.5 kDa (380aa) |
Purity : | > 95% by SDS - PAGE |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Pathways : | Acute myeloid leukemia; Adherens junction; Alzheimer"s disease; Axon guidance; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Dorso-ventral axis formation. |
Gene Name : | MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens ] |
Synonyms : | ERK; p38; p40; p41; ERK2; ERT1; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; MAPK1;; mitogen-activated protein kinase 1; protein tyrosine kinase ERK2; mitogen-activated protein kinase 2; extracellular signal-regulated kinase 2; extracellular signal-regulated kinase-2. |
Gene ID : | 5594 |
mRNA Refseq : | NM_002745 |
Protein Refseq : | NP_002736 |
MIM : | 176948 |
UniProt ID : | P28482 |
Chromosome Location : | 22q11.2; 22q11.21 |
Function : | ATP binding; MAP kinase 2 activity; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; phosphotyrosine binding; protein binding; protein serine/threonine kinase activity; transferase activity. |
Products Types
◆ Recombinant Protein | ||
Mapk1-7394M | Recombinant Mouse Mapk1 protein(Met1-Ser358), His&GST-tagged | +Inquiry |
MAPK1-1081H | Recombinant Human MAPK1 Protein (M1-S360), Flag/His tagged | +Inquiry |
MAPK1-2417H | Recombinant Human MAPK1 Protein, His-tagged | +Inquiry |
MAPK1-385H | Recombinant Human MAPK1 Protein, MYC/DDK-tagged | +Inquiry |
MAPK1-052H | Recombinant Human MAPK1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
◆ Lysates | ||
MAPK1-001MCL | Recombinant Mouse MAPK1 cell lysate | +Inquiry |
MAPK1-692HCL | Recombinant Human MAPK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.
MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.
MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.
Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.
Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.
Customer Reviews (3)
Write a reviewWhether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.
The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
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