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Recombinant Human FXN protein, His-tagged

Cat.No. : FXN-1823H
Product Overview : Recombinant Human FXN (42-210aa) fussed with His tag was expressed in E. coli.
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Description : Frataxin, also known as FXN, is an iron binding protein which belongs to FRATAXIN family. It is an anti-apoptotic protein which prevents mitochondrial damage, reactive oxygen species production and act as either an iron chaperone or an iron storage protein. Frataxin is localized to the mitochondrion and regulating mitochondrial iron transport and respiration. Defects in this protein cause Friedreich ataxia. Recombinant Frataxin protein was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.
Molecular Mass : 21.1 kDa (190aa), confirmed by MALDI-TOF.
AA Sequence : MGSSHHHHHH SSGLVPRGSH MLRTDIDATC TPRRASSNQR GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFFEDLADKPYTF EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV SLHELLAAEL TKALKTKLDLSSLAYSGKDA
Purity : > 95% by SDS-PAGE
Storage : Can be stored at +4 centigradeshort term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : FXN frataxin [ Homo sapiens ]
Official Symbol : FXN
Synonyms : FA; X25; CyaY; FARR; FRDA; frataxin, mitochondrial; Friedreich ataxia protein
Gene ID : 2395
mRNA Refseq : NM_000144
Protein Refseq : NP_000135
MIM : 606829
UniProt ID : Q16595
Chromosome Location : 9q21.11
Pathway : HIF-2-alpha transcription factor network, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem
Function : 2 iron, 2 sulfur cluster binding; ferric iron binding; ferroxidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you elaborate on the interactions between FXN and iron regulatory proteins in the cell? 04/26/2022

FXN interacts with iron regulatory proteins, influencing cellular iron homeostasis by modulating the expression of genes involved in iron metabolism.

What is the impact of FXN deficiency on the sensitivity of cells to oxidative stress? 01/23/2021

FXN deficiency increases cellular sensitivity to oxidative stress due to the disruption of iron homeostasis, leading to the accumulation of reactive oxygen species and cellular damage.

Can you explain the chemistry behind the iron-sulfur cluster assembly facilitated by FXN? 08/28/2020

FXN assists in the formation of iron-sulfur clusters by providing a scaffold for the assembly of iron and sulfur atoms, promoting the stability and functionality of these clusters.

How does FXN contribute to the regulation of cellular energy metabolism? 02/09/2019

FXN influences cellular energy metabolism by supporting the function of iron-sulfur cluster-containing enzymes involved in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle.

How does FXN deficiency lead to Friedreich's ataxia on a molecular level? 04/05/2018

FXN deficiency results in impaired iron-sulfur cluster assembly, leading to mitochondrial dysfunction, oxidative stress, and ultimately causing Friedreich's ataxia.

Customer Reviews (3)

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Reviews
01/28/2021

    Customer service was courteous and efficient, guiding us through the product selection process with expertise.

    12/20/2019

      The consistent quality of this product has made it a staple in our lab, contributing to the success of various research projects.

      09/02/2018

        Delivery was quick and hassle-free, allowing us to proceed with our experiments without any unnecessary delays.

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