Recombinant Human FXN protein, His-tagged
Cat.No. : | FXN-1823H |
Product Overview : | Recombinant Human FXN (42-210aa) fussed with His tag was expressed in E. coli. |
- Specification
- Gene Information
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Description : | Frataxin, also known as FXN, is an iron binding protein which belongs to FRATAXIN family. It is an anti-apoptotic protein which prevents mitochondrial damage, reactive oxygen species production and act as either an iron chaperone or an iron storage protein. Frataxin is localized to the mitochondrion and regulating mitochondrial iron transport and respiration. Defects in this protein cause Friedreich ataxia. Recombinant Frataxin protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl. |
Molecular Mass : | 21.1 kDa (190aa), confirmed by MALDI-TOF. |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MLRTDIDATC TPRRASSNQR GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFFEDLADKPYTF EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV SLHELLAAEL TKALKTKLDLSSLAYSGKDA |
Purity : | > 95% by SDS-PAGE |
Storage : | Can be stored at +4 centigradeshort term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 1 mg/ml (determined by Bradford assay) |
Gene Name : | FXN frataxin [ Homo sapiens ] |
Official Symbol : | FXN |
Synonyms : | FA; X25; CyaY; FARR; FRDA; frataxin, mitochondrial; Friedreich ataxia protein |
Gene ID : | 2395 |
mRNA Refseq : | NM_000144 |
Protein Refseq : | NP_000135 |
MIM : | 606829 |
UniProt ID : | Q16595 |
Chromosome Location : | 9q21.11 |
Pathway : | HIF-2-alpha transcription factor network, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem |
Function : | 2 iron, 2 sulfur cluster binding; ferric iron binding; ferroxidase activity |
Products Types
◆ Recombinant Protein | ||
FXN-1397M | Recombinant Mouse FXN Protein (78-207 aa), His-tagged | +Inquiry |
Fxn-1218R | Recombinant Rat Fxn Protein, His-tagged | +Inquiry |
FXN-3398M | Recombinant Mouse FXN Protein, His (Fc)-Avi-tagged | +Inquiry |
FXN-4576H | Recombinant Human FXN Protein, GST-tagged | +Inquiry |
FXN-275C | Recombinant Cynomolgus Monkey FXN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FXN-6108HCL | Recombinant Human FXN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFXN interacts with iron regulatory proteins, influencing cellular iron homeostasis by modulating the expression of genes involved in iron metabolism.
FXN deficiency increases cellular sensitivity to oxidative stress due to the disruption of iron homeostasis, leading to the accumulation of reactive oxygen species and cellular damage.
FXN assists in the formation of iron-sulfur clusters by providing a scaffold for the assembly of iron and sulfur atoms, promoting the stability and functionality of these clusters.
FXN influences cellular energy metabolism by supporting the function of iron-sulfur cluster-containing enzymes involved in key metabolic pathways, such as the tricarboxylic acid (TCA) cycle.
FXN deficiency results in impaired iron-sulfur cluster assembly, leading to mitochondrial dysfunction, oxidative stress, and ultimately causing Friedreich's ataxia.
Customer Reviews (3)
Write a reviewCustomer service was courteous and efficient, guiding us through the product selection process with expertise.
The consistent quality of this product has made it a staple in our lab, contributing to the success of various research projects.
Delivery was quick and hassle-free, allowing us to proceed with our experiments without any unnecessary delays.
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