"FXN" Related Products

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Recombinant Human FXN protein, His-tagged

Cat.No. : FXN-1823H
Product Overview : Recombinant Human FXN (42-210aa) fussed with His tag was expressed in E. coli.
Description : Frataxin, also known as FXN, is an iron binding protein which belongs to FRATAXIN family. It is an anti-apoptotic protein which prevents mitochondrial damage, reactive oxygen species production and act as either an iron chaperone or an iron storage protein. Frataxin is localized to the mitochondrion and regulating mitochondrial iron transport and respiration. Defects in this protein cause Friedreich ataxia. Recombinant Frataxin protein was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1 M NaCl.
Molecular Mass : 21.1 kDa (190aa), confirmed by MALDI-TOF.
AA Sequence : MGSSHHHHHH SSGLVPRGSH MLRTDIDATC TPRRASSNQR GLNQIWNVKK QSVYLMNLRK SGTLGHPGSL DETTYERLAE ETLDSLAEFFEDLADKPYTF EDYDVSFGSG VLTVKLGGDL GTYVINKQTP NKQIWLSSPS SGPKRYDWTG KNWVYSHDGV SLHELLAAEL TKALKTKLDLSSLAYSGKDA
Purity : > 95% by SDS-PAGE
Storage : Can be stored at +4 centigradeshort term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : FXN frataxin [ Homo sapiens ]
Official Symbol : FXN
Synonyms : FA; X25; CyaY; FARR; FRDA; frataxin, mitochondrial; Friedreich ataxia protein
Gene ID : 2395
mRNA Refseq : NM_000144
Protein Refseq : NP_000135
MIM : 606829
UniProt ID : Q16595
Chromosome Location : 9q21.11
Pathway : HIF-2-alpha transcription factor network, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem
Function : 2 iron, 2 sulfur cluster binding; ferric iron binding; ferroxidase activity

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