| Cat. No. : |
CXCL10-148S |
| Description : |
Chemokine (C-X-C motif) ligand 10 (CXCL10) or IP-10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (γ-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts. |
| Source : |
Yeast. |
| Sequences Of Amino Acids : |
PLSRTVRCTC IKISDRPVNP RSLEKLEMIP ASQSCPHVEI IATMKKNGEK RCLNPESKTI KNLLKAISKE RSKRSPRTQR EA. |
| Formulation/ Reconstitution : |
Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
| Purity : |
>95% as visualized by SDS-PAGE analysis. |
| Purification : |
Ion-exchange chromatography. |
| Biological Activity : |
The biological activity of recombinant swine CXCL10 was determined in a chemotaxis assay using a Boyden chamber. Swine PBMCs were activated with PHA for 3 days followed by treatment with IL-2. Bioactivity is typically detected at 10 ng/mL. |
| Storage : |
Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |
| Pathways : |
Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; RIG-I-like receptor signaling pathway; Toll-like receptor signaling pathway |
