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| Cat. No.: | VEGFA-389H |
| Product Overview: | Recombinant Humanvascular endothelial growth factor109 was expressed inE.coli. |
| Description: | Vascular endothelial growth factor (VEGF) is a member of the cysteine-knot growth factor superfamily. Five VEGF splice variants exist including VEGF-121, VEGF-145, VEGF-165, VEGF-189; and VEGF-206. VEGF-165 is the most abundant and active isoform. VEGF-165 functions as a growth factor in angiogenesis, vasculogenesis and endothelial cell growth. VEGF-165 acts as a specific mitogen and survival factor for vascular endothelial cells, inducing microvascular permeability, cell migration and regulates the differentiation and survival of hematopoietic progenitor cells to affect hematopoiesis, immune function and tumour progression. VEGF-165 also plays roles in neurogenesis and blood brain barrier function. |
| Source: | E.coli. |
| Amino Acid Sequence: | GQNHHEVVK F MDVYQRS YCH PIETLV DIFQ EYPD EIEYIF KPSCVPL MRC GGC C NDEGLE CVPTEESNIT MQIMRIKPHQ GQHIGEMSFL QHNKCECRPKKDHHHH. |
| Molecular Mass: | VEGF-109 migrates as a 14 kDa in SDS-PAGE. |
| PI: | human VEGF-109 has a predicted pI of 5.3-6.0. |
| Purification: | 97%, as determined by SDS-PAGE and visualized by silver stain. |
| Appearance: | Transparent liquid. |
| Formulation: | rh-VEGF109, 10 mM NaAc, pH 5.5, 4% Manitol. |
| Storage: | At 4℃ for 12 months. |
| Gene Name: | VEGFA vascular endothelial growth factor A [ Homo sapiens ] |
| Synonyms: | vascular endothelial growth factor A; VPF; VEGF; MVCD1; VEGF-A; MGC70609; VEGFA; vascular permeability factor; vascular endothelial growth factor isoform VEGF165; Vascular permeability factor |
| Gene ID: | 7422 |
| mRNA Refseq: | NM_001025366 |
| Protein Refseq: | NP_001020537 |
| MIM: | 192240 |
| UniProt ID: | P15692 |
| Chromosome Location: | 6p12 |
| Pathway: | Bladder cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Pancreatic cancer; Pathways in cancer; Renal cell carcinoma; VEGF signaling pathway; mTOR signaling pathway; Hemostasis; Signaling by VEGF |
| Function: | cell surface binding; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; heparin binding; platelet-derived growth factor receptor binding; protein homodimerization activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding |
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