"DKK" Related Products

Recombinant Human Dickkopf Homolog 1 (Xenopus laevis)

Cat. No.: DKK1-1975H.
Product Overview: Recombinant Human dickkopf homolog 1 (Xenopus laevis) is expressed inE. coli.DKK1 is a 35-40 kDa glycoprotein that contains 235 amino-acid residues.
Description: Recombinant Human DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis.
Source: E. coli.
Purity: Greater than 97% by SDS-PAGE gel and HPLC analyses.
Endotoxin: Endotoxin level is less than 0.1 ng per μg (1EU/μg).
AA Sequence: TLNSVLNSNAIKNL PPPLGGAAGHPGSAVS AAPGILYPGGNKYQ TIDNYQPYPCAE DEECGTD EYCASPTRGG DAGVQICLACR KRRKRCMR HAMCCPGN YCKNGI CVSS DQNHFRGEIE ETITE SFGNDHSTLDGYSRR TTLSSKMYHT KGQEGS VCLR SSDCASGLCCARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLS CRIQK DH HQASNSSRLH TCQRH.
Storage: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted DKK-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze/thaw cycles.
Gene Name: DKK1 dickkopf homolog 1 (Xenopus laevis) [ Homo sapiens ]
Synonyms: dickkopf homolog 1 (Xenopus laevis); DKK1; SK; DKK-1; Dkk-1; HDKK1; HDKK-1; Dickkopf-1; Dickkopf-related protein 1; Dickkopf related protein-1; dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1; hDkk-1
Gene ID: 22943
mRNA Refseq: NM_ 012242
Protein Refseq: NP_ 036374
MIM: 605189
UniProt ID: O94907
Chromosome Location: 10q11.2
Pathway: Wnt signaling pathway
Function: growth factor activity; low-density lipoprotein receptor binding; protein binding; signal transducer activity

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