Recombinant Human Dickkopf Homolog 1 (Xenopus laevis)
| Cat.No. : | DKK1-1975H |
| Product Overview : | Recombinant Human dickkopf homolog 1 (Xenopus laevis) is expressed inE. coli.DKK1 is a 35-40 kDa glycoprotein that contains 235 amino-acid residues. |
- Specification
- Gene Information
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| Cat. No. : | DKK1-1975H. |
| Description : | Recombinant Human DKK-1 is a member of the DKK protein family which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. Subsequent studies have shown that DKK-1 and DKK-4 play an important regulatory role in the Wnt /β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/βcatenin signaling system. LPR5 and LPR6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/βcatenin signaling cascade. It has been suggested that by inhibiting Wnt/β-catenin signaling, which is essential for posterior patterning in vertebrates, DKK-1 permits anterior development. This notion is supported by the finding that mice deficient of DKK-1 expression lack head formation and die during embryogenesis. |
| Source : | E. coli. |
| Purity : | Greater than 97% by SDS-PAGE gel and HPLC analyses. |
| Endotoxin : | Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
| AA Sequence : | TLNSVLNSNAIKNL PPPLGGAAGHPGSAVS AAPGILYPGGNKYQ TIDNYQPYPCAE DEECGTD EYCASPTRGG DAGVQICLACR KRRKRCMR HAMCCPGN YCKNGI CVSS DQNHFRGEIE ETITE SFGNDHSTLDGYSRR TTLSSKMYHT KGQEGS VCLR SSDCASGLCCARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLS CRIQK DH HQASNSSRLH TCQRH. |
| Storage : | The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted DKK-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze/thaw cycles. |
| Gene Name : | DKK1 dickkopf homolog 1 (Xenopus laevis) [ Homo sapiens ] |
| Synonyms : | dickkopf homolog 1 (Xenopus laevis); DKK1; SK; DKK-1; Dkk-1; HDKK1; HDKK-1; Dickkopf-1; Dickkopf-related protein 1; Dickkopf related protein-1; dickkopf (Xenopus laevis) homolog 1; dickkopf homolog 1; hDkk-1 |
| Gene ID : | 22943 |
| mRNA Refseq : | NM_ 012242 |
| Protein Refseq : | NP_ 036374 |
| MIM : | 605189 |
| UniProt ID : | O94907 |
| Chromosome Location : | 10q11.2 |
| Pathway : | Wnt signaling pathway |
| Function : | growth factor activity; low-density lipoprotein receptor binding; protein binding; signal transducer activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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