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Recombinant Human Dihydrolipoamide Dehydrogenase, His-tagged

Cat. No.: DLD-2036H
Product Overview: Recombinant human dihydrolipoamide dehydrogenase protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW=54.4 kDa (511aa).
Description: DLD (Dihydrolipoamide dehydrogenase), also known as GCSL (glycine cleavage system L protein), is a component of the glycine cleavage system as well as of the alpha ketoacid dehydrogenase complexes. DLD is a flavin-dependent oxidoreductase and functions as a component of the α-keto acid dehydrogenase, the pyruvate dehydrogenase, the α-ketoglutarate dehydrogenase, the branched-chain α-keto acid dehydrogenase and as the L protein in the mitochondrial glycine cleavage system. Mutations in DLD protein can result in MSUD (maple syrup urine disease) and congenital infantile lactic acidosis.
Source: Escherichia Coli.
Sequences Of Amino Acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMADQ PIDADVTVIG SGPGGYVAAI KAAQLGFKTV CIEKNETLGG TCLNVGCIPS KALLNNSHYY HMAHGKDFAS RGIEMSEVRL NLDKMMEQKS TAVKALTGGI AHLFKQNKVV HVNGYGKITG KNQVTATKAD GGTQVIDTKN ILIATGSEVT PFPGITIDED TIVSSTGALS LKKVPEKMVV IGAGVIGVEL GSVWQRLGAD VTAVEFLGHV GGVGIDMEIS KNFQRILQKQ GFKFKLNTKV TGATKKSDGK IDVSIEAASG GKAEVITCDV LLVCIGRRPF TKNLGLEELG IELDPRGRIP VNTRFQTKIP NIYAIGDVVA GPMLAHKAED EGIICVEGMA GGAVHIDYNC VPSVIYTHPE VAWVGKSEEQ LKEEGIEYKV GKFPFAANSR AKTNADTDGM VKILGQKSTD RVLGAHILGP GAGEMVNEAA LALEYGASCE DIARVCHAHP TLSEAFREAN LAASFGKSIN F.
Purity: > 95% by SDS–PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Form: Liquid. In 20 mM Tris–HCl buffer (pH8.0) containing 1mM DTT, 0.1M NaCl, 10% glycerol.
Storage: Can be stored at +4℃ short term (1-2 weeks). For long term storage, aliquot and store at -20℃ or -70℃. Avoid repeated freezing and thawing cycles.
Gene Name: DLD dihydrolipoamide dehydrogenase [ Homo sapiens ]
Synonyms: DLD; dihydrolipoamide dehydrogenase; E3; LAD; DLDH; GCSL; PHE3; DLDCitrate; dihydrolipoyl dehydrogenase, mitochondrial; diaphorase; lipoamide reductase; lipoyl dehydrogenase; lipoamide dehydrogenase; glycine cleavage system L protein; glycine cleavage system protein L; E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex; EC 1.8.1.4; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Dihydrolipoyl dehydrogenase, mitochondrial; OTTHUMP00000206749; dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex
Gene ID: 1738
mRNA Refseq: NM_000108
Protein Refseq: NP_000099
MIM: 238331
UniProt ID: P09622
Chromosome Location: 7q31-q32
Pathway: cycle (TCA cycle); Glycine, serine and threonine metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways; Pyruvate metabolism; Valine, leucine and isoleucine degradation; Diabetes pathways; Integration of energy metabolism; Metabolism of amino acids and derivatives; Pyruvate metabolism and Citric Acid (TCA) cycle
Function: FAD binding; NAD or NADH binding; dihydrolipoyl dehydrogenase activity; electron carrier activity; lipoamide binding; oxidoreductase activity

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