Recombinant Human MAP2K1, His-tagged
Cat.No. : | MAP2K1-596H |
Product Overview : | Recombinant Human MAP2K1 produced inSf9cells is a glycosylated, polypeptide chain containing amino acids 2-393 having a molecular mass of 47 kDa. MAP2K1 is fused to a his tag and is purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Cat. No. : | MAP2K1-596H |
Description : | MAP2K1 is a member of the dual specificity protein kinase family, which plays a role as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, are recognized as extracellular signal-regulated kinases (ERKs), that act as an integration position for multiple biochemical signals. MEK1 is located upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As a key player of MAP kinase signal transduction pathway, MEK1 is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. |
Source : | Sf9 Insect Cells. |
Physical Appearance : | Sterile Filtered clear solution. |
Formulation : | MEK1 is supplied at a concentration of 0.09mg/ml in 40mM Tris, pH-8, 0.15M NaCl, 0.27M sucrose, 1mM DTT, 0.2mM PMSF, 1mM benzamidine, 0.1mM sodium vanadate and 0.03% Brij-35. |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Biological Activity : | ~125-175 units/mg. One unit of MEK1 activity transfers 1 nmol of phosphate to ERK1/2 peptide per minute at 30°C in a reaction containing 100μM ATP. Recombinant active MEK1 also phosphorylates ERK1, ERK2, and GSK-3α. Kinase activity may vary depending on the substrate and reaction conditions. The optimal concentration should be determined for each specific application. Storage Conditions: Store at 4°C if entire vial will be used within 1-2 weeks. Store frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
Gene Name : | MAP2K1 mitogen-activated protein kinase kinase 1 [ Homo sapiens ] |
Synonyms : | MAP2K1; mitogen-activated protein kinase kinase 1; MEK1; MKK1; MAPKK1; PRKMK1; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); EC 2.7.12.2; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1 |
Gene ID : | 5604 |
mRNA Refseq : | NM_002755 |
Protein Refseq : | NP_002746 |
MIM : | 176872 |
UniProt ID : | Q02750 |
Chromosome Location : | 15q22.1-q22.33 |
Pathway : | Acute myeloid leukemia; B cell receptor signaling pathway; Bladder cancer; Chemokine signaling pathway; Chronic myeloid leukemia; Colorectal cancer; Dorso-ventral axis formation; Endometrial cancer; ErbB signaling pathway; Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Focal adhesion; Gap junction; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term depression; Long-term potentiation; MAPK signaling pathway; Melanogenesis; Melanoma; Natural killer cell mediated cytotoxicity; Neurotrophin signaling pathway; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prion diseases |
Function : | ATP binding; MAP kinase kinase activity; Ras GTPase binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; receptor signaling protein tyrosine phosphatase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
MAP2K1-2483R | Recombinant Rhesus Macaque MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Map2k1-3920M | Recombinant Mouse Map2k1 Protein, Myc/DDK-tagged | +Inquiry |
MAP2K1-1307M | Recombinant Mouse MAP2K1 protein(Met1-Ile393) | +Inquiry |
MAP2K1-3430H | Recombinant Human MAP2K1 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP2K1-1310M | Recombinant Mouse MAP2K1 protein(Met1-Ile393), His&GST-tagged | +Inquiry |
◆ Lysates | ||
MAP2K1-001MCL | Recombinant Mouse MAP2K1 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1614 | MEK1 Kinase Binding Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, there are clinical trials exploring the efficacy and safety of MAP2K1 inhibitors in various cancers and other diseases.
Some diagnostic tests may analyze MAP2K1 mutations, especially in the context of cancer, to inform treatment decisions.
MAP2K1 mutations can serve as biomarkers in cancer diagnostics, aiding in the identification and classification of tumors.
MAP2K1 mutations can be associated with resistance to certain cancer therapies, making it important to understand its role in treatment response.
Yes, MAP2K1 inhibitors are being explored as targeted therapies in cancer treatment, aiming to block the abnormal signaling associated with MAP2K1 mutations.
Customer Reviews (3)
Write a reviewThe unmatched performance of the MAP2K1 protein in both ELISA assays and protein electron microscopy structure analysis showcases its versatility and reliability in various experimental settings.
The MAP2K1 protein finds extensive utility in protein electron microscopy structure analysis.
With its exceptional specificity and sensitivity, it enables precise and reliable detection of target molecules, making it a valuable tool in the field of diagnostic and research applications.
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