Recombinant Human Caspase 4, Apoptosis-related Cysteine Peptidase
Cat.No. : | CASP4-599H |
Product Overview : | Recombinant Human CASP4 was produced inE. coli. |
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Cat. No. : | CASP4-599H |
Description : | Caspase-4 is a member of the caspase family of cysteine proteases. It exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-4 is routinely tested for its ability to enzymatically cleave the substrate WEHD-AFC or WEHD-pNA. |
Source : | E. coli. |
Purity : | ≥95% (SDS-PAGE). |
Formulation : | Lyophilized. |
Reconstitution : | Reconstitute with PBS containing 15% glycerol to 1U/µl. |
Specific Activity : | ~5"000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate WEHD-pNA per hour at 37°C in reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT. |
Application : | Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity. |
Storage : | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80℃. |
Gene Name : | CASP4 caspase 4, apoptosis-related cysteine peptidase [ Homo sapiens ] |
Synonyms : | CASP4; caspase 4, apoptosis-related cysteine peptidase; TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II; caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57;TX protease; Caspase-4 subunit 1; Caspase-4 subunit 2; ICH2 |
Gene ID : | 837 |
mRNA Refseq : | NM_001225 |
Protein Refseq : | NP_001216 |
MIM : | 602664 |
UniProt ID : | P49662 |
Chromosome Location : | 11q22.2-q22.3 |
Function : | cysteine-type endopeptidase activity; peptidase activity; protein binding |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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