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Recombinant Mouse Indoleamine 2,3-dioxygenase 1, His-tagged

Cat. No. : Ido1-2126M
Product Overview : Recombinant Mouse Ido1 was produced inE. coli.Mature mouse IDO (indoleamine 2,3-dioxygenase) (aa 1-407) is fused at the C-terminus to a His-tag.
Description : Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells (also used as an immune subversion strategy by many tumors). IDO is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells.
Source : E. coli.
Purity : ≥90% (SDS-PAGE).
Formulation : Liquid. 0.2µm-filtered solution in 50mM TRIS, pH 7.4, containing 1mM EDTA.
Concentration : 1mg/ml.
Endotoxin Content : <1EU/µg protein (LAL-test).
Specific Activity : >100'000U/mg protein with L-tryptophan as substrate. One unit is defined as the amount of enzyme that produces 1nmol of kynurenine per hour.
Storage : Working aliquots are stable for up to 3 months when stored at -20°C.
Gene Name : Ido1 indoleamine 2,3-dioxygenase 1 [ Mus musculus ]
Synonyms : Ido1; indoleamine 2,3-dioxygenase 1; Ido; Indo; IDO-1; OTTMUSP00000022551; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; EC 1.13.11.52
Gene ID : 15930
mRNA Refseq : NM_008324
Protein Refseq : NP_032350
UniProt ID : P28776
Chromosome Location : 8 A2
Pathway : Metabolic pathways; Tryptophan metabolism
Function : amino acid binding; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; oxygen binding; tryptophan 2,3-dioxygenase activity

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