"PDCD6IP" Related Products

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Recombinant Human PDCD6IP, His-tagged

Cat. No.: PDCD6IP-1938H
Product Overview: Recombinant PDCD6IP protein fused to his-tag was expressed inE.coliand purified by using conventional chromatography techniques, 45.8 kDa (412aa).
Description: Alix, also known as PDCD6IP, is a cytoplasmic protein that interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. It's involved in concentration and sorting of cargo proteins of the multivesicular body for incorporation into intralumenal vesicles that are generated by invagination and scission from the limiting membrane of the endosome. Overexpression of this protein and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.
Source: E.coli.
Purity: > 95% by SDS – PAGE.
Physical Appearance: Liquid.
Formulation: In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LA.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: PDCD6IP programmed cell death 6 interacting protein [ Homo sapiens ]
Synonyms: PDCD6IP; programmed cell death 6 interacting protein; AIP1; Alix; HP95; DRIP4; MGC17003; programmed cell death 6-interacting protein; PDCD6-interacting protein; ALG-2 interacting protein 1; ALG-2 interacting protein X; ALG-2-interacting protein 1; dopamine receptor interacting protein 4; apoptosis-linked gene 2-interacting protein X; KIAA1375
Gene ID: 10015
mRNA Refseq: NM_001162429
Protein Refseq: NP_001155901
MIM: 608074
UniProt ID: Q8WUM4
Chromosome Location: 3p22.3
Pathway: Endocytosis
Function: calcium-dependent protein binding; protein binding

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