Recombinant Human SELE protein, His-tagged
Cat.No. : | SELE-2242H |
Product Overview : | Recombinant Human SELE (Trp22-Pro556) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293). |
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Description : | E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Trp22 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 60 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Trp22-Pro556 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | SELE |
Official Symbol : | SELE |
Synonyms : | SELE; selectin E; ELAM, ELAM1, endothelial adhesion molecule 1; E-selectin; CD62E; ESEL; ELAM-1; endothelial adhesion molecule 1; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; ELAM; ELAM1; LECAM2 |
Gene ID : | 6401 |
mRNA Refseq : | NM_000450 |
Protein Refseq : | NP_000441 |
MIM : | 131210 |
UniProt ID : | P16581 |
Products Types
◆ Recombinant Protein | ||
Sele-4093R | Active Recombinant Rat Sele protein(Met1-Pro494), His-tagged | +Inquiry |
SELE-05H | Active Recombinant Human SELE Protein, His-tagged | +Inquiry |
SELE-839M | Recombinant Mouse SELE Protein (Met1-Pro564) | +Inquiry |
Sele-5755M | Recombinant Mouse Sele Protein, Myc/DDK-tagged | +Inquiry |
SELE-210H | Recombinant Human SELE Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
SELE-2992HCL | Recombinant Human SELE cell lysate | +Inquiry |
SELE-960RCL | Recombinant Rat SELE cell lysate | +Inquiry |
SELE-845MCL | Recombinant Mouse SELE cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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