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Recombinant Mouse Caspase 9

Cat. No.: Casp9-679M
Description: Caspase-9 is an initiator caspase encoded by the CASP9 gene. CASP9 orthologs have been identified in all mammals for which complete genome data are available. Unique orthologs are also present in lizards, lissamphibians, and teleosts. The aspartic acid specific protease caspase-9 has been linked to the mitochondrial death pathway. It is activated during programmed cell death (apoptosis). Induction of stress signalling pathways JNK/SAPK causes release of cytochrome c from mitochondria and activation of apaf-1 (apoptosome), which in turn cleaves the pro-enzyme of caspase-9 into the active form. Once initiated caspase-9 goes on to cleave procaspase-3 & procaspase-7 and which cleave several cellular targets, including poly ADP ribose polymerase.
Source/Host: E. coli.
Concentration: 0.57mg/ml.
Purity: 90% (SDS-PAGE).
Short Term Storage: -20°C.
Formulation: Liquid. In 20mM TRIS-HCl, pH 8.5.
Long Term Storage: -80°C.
Use/Stability: Stability at -20°C: 1-2 weeks.
Handling: Avoid freeze/thaw cycles.
Gene Name: Casp9 caspase 9 [ Mus musculus ]
Synonyms: caspase 9; Mch6; AI115399; AW493809; ICE-LAP6; Caspase-9; Casp9; caspase-9; OTTMUSP00000010525
Gene ID: 12371
mRNA Refseq: NM_015733
Protein Refseq: NP_056548
Chromosome Location: 4 E1
Pathway: Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Colorectal cancer; Endometrial cancer; Huntington"s disease; Non-small cell lung cancer; Pancreatic cancer; Parkinson"s disease; Pathways in cancer; Prostate cancer; Small cell lung cancer; VEGF signaling pathway; Viral myocarditis; p53 signaling pathway
Function: cysteine-type peptidase activity; hydrolase activity; peptidase activity; peptide binding; protein binding

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