"SIGIRR" Related Products

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Recombinant Human SIGIRR, Fc Chimera

Cat. No. : SIGIRR-2422H
Product Overview : Recombinant signal peptide and extracellular domain of human SIGIRR (aa 1-118) produced inHEK 293 cellsare fused at the C-terminus to the Fc portion of human IgG.
Description : Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family. It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling. It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.
Source/Host : HEK 293 cells.
Purity : ≥90% (SDS-PAGE).
Endotoxin Content : <0.1EU/µg protein (LAL-test).
Formulation : Liquid. 0.2µm-filtered solution in PBS.
Long Term Storage : -20°C.
Use/Stability : Working aliquots are stable for up to 3 months when stored at -20°C.
Handling : After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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