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Recombinant Human Paxillin, GST-tagged

Cat. No.: PXN-2413H
Product Overview: Recombinant Human paxillin encoding 356-558 aa was expressed inE. coli.It was fused with a GST tag at the N-terminus.
Description: Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.
Source: E. coli.
Presentation: 100μl purified human Lyn protein at 100μg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol without BSA and Sodium Azide.
Applications: ELISA•Inhibition Assays• Western Blotting.
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48 kDa (including GST).
Storage & Stability: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months.
Gene Name: PXN paxillin [ Homo sapiens ]
Synonyms: PXN; paxillin; FLJ16691; Paxillin
Gene ID: 5829
mRNA Refseq: NM_001080855
Protein Refseq: NP_001074324
UniProt ID: P49023
Chromosome Location: 12q24
MIM: 602505
Pathway: Chemokine signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; VEGF signaling pathway; Cell junction organization; Muscle contraction; Signaling by EGFR
Function: metal ion binding; protein binding; vinculin binding; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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