||Recombinant Mouse Retinoic Acid Receptor Responder (Tazarotene Induced) 2 is expressed inE. coli.
||Chemerin is a potent chemoattractant, identified as the ligand of CMKLR (also known as Chem23R, DEZ), a receptor expressed by plasmacytoid DCs, and some macrophage and NK cell subsets. Pro-chemerin circulates in the blood and is biologically inactive, until processed by a variety of serine proteases at sites of tissue damage to remove six C-terminal amino acid residues. The cleaved, mature form of chemerin is biologically active and recruits CMKLR1-positive cells to sites of tissue damage. Chemerin is a member of the cystatin superfamily and contains three intrachain disulfide bonds.
||>98% pure as demonstrated by SDS-gel electrophoresis and reverse phase HPLC.
||Less than 0.01 ng/ug cytokine, as determined by the LAL assay.
||Measured in a bioassay of chemerin-induced migration of CHO cells transfected with the mouse chemerin receptor, CMKLR. Maximal chemotactic activity of chemerin in this assay is typically observed at 50-100 ng/ml.
||Sterile liquid; phosphate buffered saline, pH 7.2,150 mM NaCl, with 0.5% BSA, 0.22 μM filtered.
||Store at less than or equal to -70°C.