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Recombinant Human SNRPF, His-tagged

Cat. No.: SNRPF-3366H
Product Overview: Recombinant human SNRPF protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW = 11.8 kDa (106aa).
Description: Small nuclear ribonucleoprotein polypeptide F, also known SNRPF, belongs to the snRNP Sm proteins family. There are at least seven isoforms, E, F, G, D1, D2, D3 and B/B. This class of common proteins plays an essential role in the biogenesis of the snRNPs. In addition, these proteins represent the major targets for the so-called anti-Sm auto-antibodies which are diagnostic for systemic lupus erythematosus (SLE). SNRPF aid in the cytoplasmic construction of the UsnRNPs by binding to aconserved Sm site on UsnRNA and forming a stable snRNP core complex.
Source: E.coli.
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 1mM EDTA.
Purity: > 95% by SDS - PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSLPLNPKPF LNGLTGKPVM VKLKWGMEYKG Y LVSVDGYM NMQLANTEEYIDGALSGHLG EVLIRCNNVLYIRGVEEEEEDGE M R E .
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Spliceosome; Gene Expression; Metabolism of RNA; Transcription; mRNA Processing
Gene Name: SNRPF small nuclear ribonucleoprotein polypeptide F [ Homo sapiens ]
Synonyms: small nuclear ribonucleoprotein polypeptide F;SMF; Sm-F; SNRPF; snRNP-F; sm protein F; Sm protein F; small nuclear ribonucleoprotein F; PBSCF
Gene ID: 6636
mRNA Refseq: NM_003095
Protein Refseq: NP_003086
MIM: 603541
UniProt ID: P62306
Chromosome Location: 12q23.1
Function: protein binding; RNA binding

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