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Recombinant Mouse Anpep, His tagged

Cat.No. : Anpep-905M
Product Overview : Recombinant Mouse Anpep metalloprotease domain (Lys 66-Ser 966) (NP_032512.2), fused with a C-terminal polyhistidine tag, was produced in Human Cell.
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Source : Human Cells
Species : Mouse
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4
Molecular Mass : The recombinant mouse ANPEP consists of 909 amino acids and has a calculated molecular mass of 104 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 120-130 kDa protein in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : Anpep alanyl (membrane) aminopeptidase [ Mus musculus ]
Official Symbol : Anpep
Gene ID : 16790
mRNA Refseq : NM_008486
Protein Refseq : NP_032512

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (13)

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Does ANPEP protein have any diagnostic or prognostic significance? 01/14/2023

ANPEP protein expression has been investigated as a potential diagnostic and prognostic marker in certain diseases. For example, increased ANPEP expression has been observed in certain cancers, such as colorectal cancer, and may serve as a biomarker for disease progression or response to treatment. However, further research is still needed to establish its clinical significance.

Are there any known genetic variations or mutations in the ANPEP gene? 08/30/2022

Yes, various genetic variations and mutations have been identified in the ANPEP gene. Some of these variations may influence ANPEP protein expression, activity, or function, and have been associated with certain diseases or conditions. For example, certain genetic variants of ANPEP have been linked to an increased risk of developing inflammatory bowel diseases.

Are there any drugs or therapies targeting ANPEP protein? 06/18/2022

There are currently no specific drugs or therapies that directly target ANPEP protein. However, the knowledge about the involvement of ANPEP in certain diseases, such as viral infections and IBD, may help guide the development of potential therapies. For example, research is ongoing to develop antiviral drugs that can inhibit the interaction between ANPEP and viral particles.

Are there any diseases or conditions associated with ANPEP protein? 06/12/2020

Yes, ANPEP protein has been implicated in various diseases. For example, it has been linked to viral infections, such as human coronavirus infections, as the ANPEP protein acts as a receptor for the virus to enter host cells. ANPEP has also been associated with inflammatory bowel diseases (IBD) and renal diseases, where its expression and activity levels may be altered.

Are there any known inhibitors or activators of ANPEP protein? 06/03/2020

Several compounds have been identified as inhibitors or activators of ANPEP protein. For example, amastatin and bestatin are known inhibitors that can block the enzymatic activity of ANPEP. These inhibitors have been used in research to investigate the function of ANPEP and its role in various physiological and pathological processes. On the other hand, activators of ANPEP are less well-studied, and more research is needed to identify specific compounds that can modulate ANPEP activity.

Is ANPEP protein expressed in all tissues of the body? 04/18/2020

ANPEP protein is not expressed in all tissues of the body. Its expression is generally highest in tissues and organs that have high metabolic activity, such as the kidneys, small intestine, and lung. ANPEP is also found in other tissues, including the liver, brain, spleen, and immune cells.

How is ANPEP protein synthesized? 04/04/2019

The ANPEP protein is synthesized through a process called translation. The ANPEP gene is transcribed into messenger RNA (mRNA) in the cell nucleus. The mRNA is then exported to the cytoplasm, where it serves as a template for the synthesis of ANPEP protein. Ribosomes, along with transfer RNA (tRNA) molecules carrying specific amino acids, bind to the mRNA and catalyze the assembly of amino acids in the correct sequence to form the ANPEP protein.

Can ANPEP protein be used for diagnostic purposes? 07/15/2018

ANPEP protein expression has been investigated as a potential diagnostic marker in various diseases. For example, increased ANPEP expression has been observed in certain cancers and may serve as a biomarker for disease detection, prognosis, or response to treatment. Additionally, ANPEP expression in the kidneys has been evaluated as a marker for kidney function. However, further research and validation are required before ANPEP can be routinely used for diagnostic purposes.

Can ANPEP protein be used as a therapeutic target for any diseases? 11/27/2017

While there are currently no approved therapies specifically targeting ANPEP protein, it is being investigated as a potential therapeutic target for certain diseases. For example, in cancer research, ANPEP is being explored as a target for antibody-based therapies, such as antibody-drug conjugates or immunotoxins, to selectively deliver cytotoxic agents to ANPEP-expressing cancer cells. Additionally, targeting ANPEP may have potential in the treatment of viral infections by developing drugs that block the interaction between ANPEP and viral particles. However, more studies and clinical trials are needed to validate the efficacy and safety of such approaches.

Where is ANPEP protein localized in the cell? 10/21/2017

ANPEP protein is primarily localized on the surface of cells, particularly on the apical membrane of epithelial cells lining the intestines and the proximal tubules of the kidneys. It is also found on the surface of immune cells, such as T cells and neutrophils.

Is ANPEP protein expressed in other tissues besides the intestines and kidneys? 10/20/2017

Yes, ANPEP protein is expressed in various tissues and organs throughout the body, although its levels and functions may vary. It can be found in the lungs, liver, spleen, brain, reproductive organs, and immune cells like T cells and neutrophils.

Are there any genetic mutations or polymorphisms associated with ANPEP protein? 05/19/2017

Yes, genetic mutations and polymorphisms in the ANPEP gene have been identified and associated with certain diseases or physiological traits. For example, specific mutations in the ANPEP gene have been linked to familial renal glucosuria, a rare inherited disorder characterized by excess glucose in the urine. In addition, certain polymorphisms in the ANPEP gene have been associated with an increased risk of developing certain types of cancers, such as colorectal cancer and breast cancer. However, more research is needed to fully understand the functional consequences of these genetic variants and their impact on ANPEP protein function.

How is ANPEP protein involved in immune responses? 05/08/2016

ANPEP protein, expressed on the surface of immune cells, plays a role in immune responses by mediating the adhesion and migration of cells. It interacts with other immune cells and mediates the binding of immune cells to endothelial cells, which is essential for immune cell trafficking and immune responses. ANPEP also aids in the regulation of inflammatory processes.

Customer Reviews (5)

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Reviews
09/13/2022

    The knowledgeable and responsive support team offers valuable assistance and expertise, making troubleshooting and problem-solving much more efficient.

    04/24/2021

      Its purity and functionality have been extensively tested, ensuring reliable and reproducible results in my research.

      01/15/2019

        One notable advantage of using the ANPEP protein is the outstanding technical support provided by its manufacturer.

        12/10/2018

          By using the ANPEP protein in my experiments, I am confident in obtaining accurate and dependable data.

          03/15/2018

            the ANPEP protein not only fulfills my experimental requirements but is also backed by excellent technical support, which guarantees a smooth and successful research experience.

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