"UROD" Related Products

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Recombinant Human Uroporphyrinogen Decarboxylase, His-tagged

Cat. No.: UROD-730H
Product Overview: Recombinant humanUROD protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 43.0 kDa (387aa).
Description: UROD is the fifth enzyme in the human heme biosynthetic pathway and is responsible for the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are responsible for three autosomal disorders in humans: familial porphyria cutanea tarda (f-PCT), sporadic porphyria cutanea tarda (s-PCT) and hepatoerythropoietic porphyria (HEP).
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MEANGLGPQG FPELKNDTFL RAAWGEETDY TPVWCMRQAG RYLPEFRETR AAQDFFSTCR SPEACCELTL QPLRRFPLDA AIIFSDILVV PQALGMEVTM VPGKGPSFPE PLREEQDLER LRDPEVVASE LGYVFQAITL TRQRLAGRVP LIGFAGAPWT LMTYMVEGGG SSTMAQAKRW LYQRPQASHQ LLRILTDALV PYLVGQVVAG AQALQLFESH AGHLGPQLFN KFALPYIRDV AKQVKARLRE AGLAPVPMII FAKDGHFALE ELAQAGYEVV GLDWTVAPKK ARECVGKTVT LQVNLDPCAL YASEEEIGQL VKQMLDDFGP HRYIANLGHG LYPDMDPEHV GAFVDAVHKH SRLLRQN
Purity: > 95% by SDS – PAGE.
Form: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 20% glycerol 1mM DTT, 0.1M NaCl, and 1mM EDTA.
Concentration: 0.5 mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: UROD uroporphyrinogen decarboxylase [ Homo sapiens ]
Synonyms: UROD; uroporphyrinogen decarboxylase; PCT; uroporphyrinogen III decarboxylase; fifth enzyme of heme biosynthetic pathway; fifth enzyme of the heme biosynthetic pathway; EC 4.1.1.37; UPD; URO-D; OTTHUMP00000010502
Gene ID: 7389
mRNA Refseq: NM_000374
Protein Refseq: NP_000365
MIM: 176100
UniProt ID: P06132
Chromosome Location: 1p34
Pathway: Porphyrin and chlorophyll metabolism; Metabolism of porphyrins
Function: uroporphyrinogen decarboxylase activity; lyase activity

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