Recombinant Mouse Grn protein, His-tagged
Cat.No. : | Grn-3287M |
Product Overview : | Recombinant Mouse Grn protein(NP_032201.2)(Met1-Leu589), fused with His tag, was expressed in HEK293. |
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- Gene Information
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Source : | HEK293 |
Species : | Mouse |
Tag : | His |
Form : | Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Molecular Mass : | The secreted recombinant mouse Progranulin comprises 583 amino acids and has a predicted molecular mass of 63 kDa. As a result of glycosylation, the apparent molecular mass of rmGRN is approximately 70-90 kDa in SDS-PAGE under reducing conditions. |
Proteinlength : | Met1-Leu589 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 90 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | Grn granulin [ Mus musculus ] |
Official Symbol : | Grn |
Synonyms : | GRN; granulin; granulins; PEPI; PCDGF; progranulin; acrogranulin; proepithelin; PC cell-derived growth factor; epithelin; |
Gene ID : | 14824 |
mRNA Refseq : | NM_008175 |
Protein Refseq : | NP_032201 |
Products Types
◆ Recombinant Protein | ||
Grn-1065M | Recombinant Mouse Grn Protein, MYC/DDK-tagged | +Inquiry |
GRN-1022H | Recombinant Human GRN Protein, His (Fc)-Avi-tagged | +Inquiry |
GRN-5375H | Recombinant Human GRN Protein, GST-tagged | +Inquiry |
GRN-2709H | Recombinant Human GRN protein(491-570 aa), C-His-tagged | +Inquiry |
Grn-1593R | Recombinant Rat Grn Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GRN-2412MCL | Recombinant Mouse GRN cell lysate | +Inquiry |
GRN-2791HCL | Recombinant Human GRN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.
GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.
Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.
The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.
Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.
GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.
Customer Reviews (3)
Write a reviewThe outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.
Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.
This protein has a short half-life, high clearance rate, and high safety and efficacy.
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