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Recombinant Human SERPIND1, His-tagged

Cat. No.: SERPIND1-3157H
Product Overview: Recombinant Human SerpinD1 precursor (Met1-Ser499), fused with a His-tag at C-terminus, was expressed inHuman Cells.
Description: SerpinD1, also known as heparin cofactor II (HCⅡ),is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis.
Source: Human Cells.
Purity: > 97% as determined by SDS-PAGE.
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Predicted N Terminal: Gly 20.
Formulation: Lyophilized from sterile PBS , pH 7.4.
Stability: Samples are stable for up to twelve months from date of receipt at -70℃.
Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Molecular Mass: The mature recombinant human SerpinD1 consists of 491 amino acids and predicts a molecular mass of 56.4 KDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhSerpinD1 is approximately 65-70 KDa as a result of glycosylation.
Gene Name: SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 [ Homo sapiens ]
Synonyms: serpin peptidase inhibitor, clade D (heparin cofactor), member 1;HC2; LS2; HCF2; HCII; HLS2; D22S673; SERPIND1; heparin cofactor 2; serpin D1; leuserpin 2; OTTHUMP00000198451; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; Protease inhibitor leuserpin-2; Serpin D1; Heparin cofactor II
Gene ID: 3053
mRNA Refseq: NM_000185
Protein Refseq: NP_000176
MIM: 142360
UniProt ID: P05546
Chromosome Location: 22q11.2; 22q11.21
Pathway: Complement and coagulation cascades
Function: endopeptidase inhibitor activity; heparin binding; serine-type endopeptidase inhibitor activity

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