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Recombinant Human IMPDH1, His-tagged

Cat.No. : IMPDH1-2580H
Product Overview : Recombinant human IMPDH1, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =57.5 kDa (534aa).
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Cat. No. : IMPDH1-2580H
Description : Inosine-5"-monophosphate dehydrogenase 1, also known as IMPDH1 catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5"-monophosphate (IMP). Also, IMPDH1 is a ubiquitously expressed enzyme, functioning as a homotetramer, which catalyzed the rate-limiting step in de novo synthesis of guanine nucleotides. As such, it plays an important role in cyclic nucleoside metabolism within photoreceptors. Defects in the IMPDH1 gene are a cause of retinitis pigmentosa type 10.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY
Purity : > 95% by SDS – PAGE.
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol.
Concentration : 0.5mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : IMPDH1 IMP (inosine 5"-monophosphate) dehydrogenase 1 [ Homo sapiens ]
Synonyms : IMPDH1; IMP (inosine 5"-monophosphate) dehydrogenase 1; IMPD; RP10; IMPD1; LCA11; sWSS2608; DKFZp781N0678; inosine-5"-monophosphate dehydrogenase 1; IMPD 1; IMPDH 1; IMPDH-I; OTTHUMP00000212385; OTTHUMP00000212386; OTTHUMP00000212390; IMP dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; EC 1.1.1.205; retinitis pigmentosa 10 (autosomal dominant)
Gene ID : 3614
mRNA Refseq : NM_000883
Protein Refseq : NP_000874
MIM : 146690
UniProt ID : P20839
Chromosome Location : 7q31.3-q32
Pathway : Drug metabolism - other enzymes; Metabolic pathways; Purine metabolism
Function : IMP dehydrogenase activity; metal ion binding; oxidoreductase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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In which tissues or organs is IMPDH1 expressed? 12/13/2019

It is expressed in a wide range of tissues and organs, including liver, kidney, heart, muscle and immune system, among others.

What role does IMPDH1 play in immune regulation? 12/13/2019

This is involved in the regulation of purine metabolism in immune cells, affecting T cell activation and immune cell function.

What is the role of IMPDH1 in tumors? 12/02/2019

It is highly expressed in tumor cells. It is involved in the regulation of purine metabolism and nucleic acid synthesis, and plays an important role in cell proliferation and survival.

Are mutations in IMPDH1 associated with drug resistance? 10/10/2019

IMPDH1 mutations may be associated with some drug resistance, because IMPDH1 is a key enzyme in purine nucleotide synthesis and plays an important role in drug treatment.

Does IMPDH1 interact with signaling pathways or molecules? 07/06/2019

The interacts with molecules such as mTOR signaling pathway, GTpase-activating proteins and uric acid.

Are IMPDH1 mutations associated with inherited diseases? 07/05/2019

Mutations in IMPDH1 can cause genetic diseases such as carnivorous syphilis, immune-related diseases and neurological disorders.

Customer Reviews (3)

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Reviews
02/15/2020

    The operation method is very simple, and accurate experimental results can be obtained easily.

    04/25/2019

      Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.

      04/12/2019

        High sensitivity, small amount can successfully complete the experiment.

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