"TXNRD1" Related Products

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Recombinant Human TXNRD1, 161-649 aa, His-tagged

Cat. No.: TXNRD1-948H
Product Overview: Recombinant human TXNRD1 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 55.9 kDa(510aa).
Description: TXNRD1, also known as Thioredoxin reductase 1, is a part of a selenium-containing pyridine nucleotide-disulphide oxidoreductase family, which has a conserved catalytic site of Cys-Val-Asn-Val-Gly-Cys. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. Inhibition of TXNRD1 activity may provide for potential treatments of cancer, AIDS and other autoimmune diseases as well as bacterial infections and parasitic diseases.
Source: E.coli.
Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) contain.ning 10% Glycerol.
Purity: > 90% by SDS - PAGE.
Concentration: 1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MYDYDLIIIG GGSGGLAAAK EAAQYGKKVM VLDFVTPTPL GTRWGLGGTC VNVGCIPKKL MHQAALLGQA LQDSRNYGWK VEETVKHDWD RMIEAVQNHI GSLNWGYRVA LREKKVVYEN AYGQFIGPHR IKATNNKGKE KIYSAERFLI ATGERPRYLG IPGDKEYCIS SDDLFSLPYC PGKTLVVGAS YVALECAGFL AGIGLDVTVM VRSILLRGFD QDMANKIGEH MEEHGIKFIR QFVPIKVEQI EAGTPGRLRV VAQSTNSEEI IEGEYNTVML AIGRDACTRK IGLETVGVKI NEKTGKIPVT DEEQTNVPYI YAIGDILEDK VELTPVAIQA GRLLAQRLYA GSTVKCDYEN VPTTVFTPLE YGACGLSEEK AVEKFGEENI EVYHSYFWPL EWTIPSRDNN KCYAKIICNT KDNERVVGFH VLGPNAGEVT QGFAAALKCG LTKKQLDSTI GIHPVCAEVF TTLSVTKRSG ASILQAGCCG.
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways: Pyrimidine metabolism; Metabolism of nucleotides
Gene Name: TXNRD1 thioredoxin reductase 1 [ Homo sapiens ]
Synonyms: thioredoxin reductase 1; TR; TR1; TXNR; TRXR1; GRIM-12; MGC9145; TXNRD1; thioredoxin reductase 1, cytoplasmic; oxidoreductase; thioredoxin reductase TR1; thioredoxin reductase GRIM-12; KM-102-derived reductase-like factor; gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; Trxr1; EC 1.8.1.9; Gene associated with retinoid-IFN-induced mortality 12 protein; Thioredoxin reductase TR1
Gene ID: 7296
mRNA Refseq: NM_001093771
Protein Refseq: NP_001087240
MIM: 601112
UniProt ID: Q16881
Chromosome Location: 12q23-q24.1
Function: FAD binding; NADP or NADPH binding; electron carrier activity; oxidoreductase activity; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity

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