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Recombinant Human CEACAM8 protein, His-tagged

Cat.No. : CEACAM8-3233H
Product Overview : Recombinant Human CEACAM8 (Gln35-Ser319) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).
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Description : Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8) is also known as CD66b (Cluster of Differentiation 66b), CD66b, CD67, CGM6, NCA-95, and is one of seven human CEACAM family members within the immunoglobulin superfamily. CEACAM family members are a set of widely expressed proteins involved in several biological functions, including cell adhesion, migration, signal transduction, and the regulation of gene expression. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. In humans, CEACAMs include type I transmembrane proteins (CEACAM1, CEACAM3, and CEACAM4) and GPI-linked molecules (CEACAM5 through CEACAM8). There is no human CEACAM2. CEACAM8 is a single chain, two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. It is an activation marker for human granulocytes.
Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Gln35
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 33.0 kDa. The protein migrates as 53-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : Gln35-Ser319
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : CEACAM8
Official Symbol : CEACAM8
Synonyms : CEACAM8; carcinoembryonic antigen-related cell adhesion molecule 8; CGM6; CD66b; CD67 antigen; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; carcinoembryonic antigen gene family member 6; CD67; NCA-95
Gene ID : 1088
mRNA Refseq : NM_001816
Protein Refseq : NP_001807
MIM : 615747
UniProt ID : P31997

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do genetic variations in the CEACAM8 gene affect immune response and susceptibility to infections? 07/24/2022

Genetic variations in CEACAM8 affect immune function and infection susceptibility.

How does CEACAM8 contribute to the activation and function of neutrophils? 12/24/2021

It aids neutrophil adhesion, migration, and antibacterial functions.

What role does CEACAM8 play in inflammatory processes and immune regulation? 09/09/2021

CEACAM8 plays a role in regulating inflammation and immune responses.

How does CEACAM8 interact with other cell adhesion molecules and signaling pathways in the immune system? 09/06/2021

CEACAM8 works with other adhesion molecules, impacting immune cell signaling.

What is the impact of altered CEACAM8 expression in autoimmune disorders and chronic inflammation? 03/22/2020

Altered CEACAM8 expression is linked to autoimmune diseases and chronic inflammation.

What potential therapeutic applications could arise from targeting CEACAM8 in immune-related diseases? 06/08/2019

Targeting CEACAM8 offers potential treatments for immune-related conditions.

What is the primary function of CEACAM8 in immune response and cell signaling? 07/07/2017

CEACAM8 is key in immune cell activation and signaling, especially in neutrophils.

Customer Reviews (3)

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12/24/2021

    Trusted partner. Contributes to our research discoveries.

    09/09/2021

      Essential for research milestones. Highly recommended service.

      07/07/2017

        Efficient and accurate. A research game-changer.

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