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Recombinant Human NEK7, His & GST tagged

Cat.No. : NEK7-761H
Product Overview : Recombinant Human NEK7 (NP_003461.2) (Met1-Ser 302), fused with the N-terminal polyhistidine-tagged GST tag, was produced in Baculovirus-Insect cells.
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Source : Baculovirus-Insect Cells
Species : Human
Tag : His & GST
Form : Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.5, 0.5mM Reduced Glutathione, 0.5mM PMSF
Molecular Mass : The recombinant human NEK7/GST chimera consists of 539 amino acids and has a calculated molecular mass of 62.4 kDa. It migrates as an approximately 58 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70oC.
Storage : Store it under sterile conditions at -20oC~-70oC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : NEK7 NIMA (never in mitosis gene a)-related kinase 7 [ Homo sapiens ]
Official Symbol : NEK7
Gene ID : 140609
mRNA Refseq : NM_133494
Protein Refseq : NP_598001
MIM : 606848
UniProt ID : Q8TDX7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you elaborate on the specific functions of NEK7 in mitosis and its contributions to spindle assembly and chromosome segregation? 04/30/2022

NEK7 is crucial for mitotic progression, contributing to spindle assembly and chromosome segregation. It phosphorylates key proteins involved in these processes, ensuring accurate distribution of genetic material during cell division.

In neurological disorders, what evidence links NEK7 to disease pathology, and what cellular processes in the nervous system involve NEK7 activity? 11/09/2021

NEK7 has been implicated in neurological disorders, with evidence linking its dysregulation to disease pathology. NEK7 activity is involved in cellular processes critical for nervous system function.

In cancer research, what evidence supports the involvement of NEK7 in tumorigenesis, and are there potential therapeutic targets associated with NEK7 dysregulation? 10/08/2020

NEK7 dysregulation is observed in various cancers, suggesting its involvement in tumorigenesis. The identification of NEK7-associated therapeutic targets holds promise for cancer treatment strategies.

How is NEK7 expression regulated, and what are the consequences of dysregulated NEK7 in cellular homeostasis and disease states? 06/19/2019

NEK7 expression is tightly regulated during the cell cycle. Dysregulation of NEK7 is associated with disruptions in cellular homeostasis and has implications in diseases such as cancer and neurodegeneration.

How does NEK7 participate in the innate immune response, particularly in the activation of the NLRP3 inflammasome, and what are the implications for inflammatory diseases? 05/02/2018

NEK7 plays a role in the innate immune response by interacting with the NLRP3 inflammasome, contributing to its activation. Dysregulation of this process is implicated in inflammatory diseases, and NEK7 is a potential therapeutic target.

Customer Reviews (3)

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Reviews
08/17/2021

    Great service, exceptional product quality

    02/13/2020

      Our lab swears by this protein. Fast shipping is a definite bonus.

      11/01/2019

        Superb quality, accompanied by excellent service.

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