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Recombinant Human GSS, His-tagged

Cat. No.: GSS-2870H
Product Overview: Recombinant human GSS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Description: Glutathione synthetase, also known GSS, is the second enzyme in theglutathionebiosynthesis pathway.It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione. Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency); also known as 5-oxoprolinuria or pyroglutamic aciduria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system.
Source: E.coli.
Sequence: MGSSHHHHQH SSGLVPRGSH MATNWGSLLQ DKQQLEELAR QAVDRALAEG VLLRTSQEPT SSEVVSYAPF TLFPSLVPSA LLEQAYAVQM DFNLLVDAVS QNAAFLEQTL SSTIKQDDFT ARLFDIHKQV LKEGIAQTVF LGLNRSDYMF QRSADGSPAL KQIEINTISA SFGGLASRTP AVHRHVLSVL SKTKEAGKIL SNNPSKGLAL GIAKAWELYG SPNALVLLIA QEKERNIFDQRAIENELLAR NIHVIRRTFE DISEKGSLDQ DRRLFVDGQE IAVVYFRDGY MPRQYSLQNW EARLLLERSH AAKCPDIATQ LAGTKKVQQE LSRPGMLEML LPGQPEAVAR LRATFAGLYS LDVGEEGDQA IAEALAAPSR FVLKPQREGG GNNLYGEEMV QALKQLKDSE ERASYILMEK IEPEPFENCL LRPGSPARVV QCISELGIFG VYVRQEKTLV MNKHVGHLLR TKAIEHADGG VAAGVAVLDN PYPV.
Purity: > 95% by SDS – PAGE.
MW: 54.5 kDa (494aa) confirmed by MALDI-TOF.
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 50mM NaCl, 0.1mM PMSF.
Concentration: 1mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: GSS glutathione synthetase [ Homo sapiens ]
Synonyms: GSS; GSHS; MGC14098; GSS; EC 6.3.2.3; GSH synthetase; glutathione synthase
Gene ID: 2937
mRNA Refseq: NM_000178
Protein Refseq: NP_000169
MIM: 601002
UniProt ID: P48637
Chromosome Location: 20q11.2
Pathway: Glutathione metabolism; Metabolic pathways; Biological oxidations
Function: glutathione binding; glutathione synthase activity; glycine binding; nucleotide binding; protein homodimerization activity

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