Recombinant Human Activin B

• Cat.No.: INHBB-2885H
• Product Overview: Human Activin B produced in Insect cells is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.

Specification

• Cat. No.: INHBB-2885H
• Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II).
• Source: Insect cells.
• Form: Lyophilized.
• Purity: 95 % (SDS-PAGE, HPLC).
• Endotoxin Level: < 0.1 ng per ug of Activin-B.
• Biological Activity: The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
• Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted Activin B is stable for at least 3 months when stored in working aliquots with a carrier protein at -20℃. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: INHBB inhibin, beta B [ Homo sapiens ]
• Synonyms: INHBB; inhibin, beta B; MGC157939; inhibin beta B chain; Inhibin, beta-2; activin beta-B chain; activin AB beta polypeptide
• Gene ID: 3625
• mRNA Refseq: NM_002193
• Protein Refseq: NP_002184
• MIM: 147390
• UniProt ID: P09529
• Chromosome Location: 2cen-q13
• Pathway: Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
• Function: cytokine activity; growth factor activity; hormone activity; host cell surface receptor binding; protein binding; protein homodimerization activity