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Recombinant Human Selenoprotein X, 1, His-tagged

Cat.No. : SEPX1-2827H
Product Overview : Recombinant human SEPX1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. MW = 14.8 kDa(136aa), confirmed by MALDI-TOF.
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Cat. No. : SEPX1-2827H
Description : SEPX1, also known as Methionine sulfoxide reductase B1 (MSRB1), is a selenoprotein. Methionine sulfoxide reductases(MSRs) catalyze reduction of free and protein-bound methionine sulfoxides to corresponding methionines. The oxidation of methionine by ROS generates a diastereomeric mixture of methionine-S-sulfoxide (Met-S-SO) and methionine-R-sulfoxide (Met-R-SO). Two distinct enzyme families evolved for reduction of these sulfoxides, with methionine-S-sulfoxide reductase (MsrA) being stereospecific for Met-S-SO and methionine-R-sulfoxide reductase (MsrB) for Met-R-SO.In bacteria, the selenocystein (Sec/U) element is located immediately following the UGA codon within the reading frame for the selenoprotein so we mutated Sec-95 to Cys.
Source : E.coli.
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI HADSVAKRPE HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFCIFSSS LKFVPKGKET SASQGH
Purity : > 90% by SDS – PAGE.
Form : Liquid. In 20 mM Tris-HCl Buffer (pH 7.5) containing 1 mM DTT, 0.1 mM PMSF, 2mM EDTA, 10% Glycerol.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Storage : Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name : SEPX1 selenoprotein X, 1 [ Homo sapiens ]
Synonyms : SEPX1; selenoprotein X, 1; SELR; SELX; MSRB1; HSPC270; MGC3344; methionine-R-sulfoxide reductase B1; selenoprotein R; methionine sulfoxide reductase; EC 1.8.4.-; Selenoprotein X
Gene ID : 51734
mRNA Refseq : NM_016332
Protein Refseq : NP_057416
MIM : 606216
UniProt ID : Q9NZV6
Chromosome Location : 16p13.3
Function : metal ion binding; oxidoreductase activity; peptide-methionine-(S)-S-oxide reductase activity; zinc ion binding

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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