| Cat.No.: | PE-2043 |
| Product Name: | TET2 protein-GST fusion |
| Background: | TET2 is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine which is involved in myelopoiesis. Defects in TET2 gene have been associated with several myeloproliferative disorders. TET2 play an important role in embryonic stem cell maintenance and inner cell mass cell specification. TET proteins have potential roles in epigenetic regulation through modification of 5mC to 5hmC. TET2 enzymatic activity is involved in myeloid tumorigenesis and this could be valuable as a diagnostic and prognostic tool for targeted therapies and to assess responses to anticancer drugs. |
| Applications: | TET2 Protein is suitable for use in Western Blot. Expect a band approximately ~124kDa on specific lysates or tissues. Specific conditions for reactivity should be optimized by the end user. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid (sterile filtered) |
| Purity: | >75% by densitometry |
| Species: | Human |
| Formulation: | 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol |
| Accession#: | NM_001127208 |
| Alternative Names: | Nbla00191, KIAA1546, MDS, Methylcytosine dioxygenase TET2 |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Protein Length: | 1197-end |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0154 | Recombinant Human TET3 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0176 | TEAD2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0215 | Human TET1 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0217 | Human TET2 Knockout Cell Line 19bp deletion | Inquiry |
| CL-0218 | Human TET3 Knockout Cell Line 14bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TEAD1 | TEAD2 | telomerase | TEN1 |
| TENR | TERF2IP | TET | TET1 |
| TET2 | TET3 | ||
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