| Cat.No.: | PE-2470 |
| Product Name: | Recombinant Human L3MBTL1 protein |
| Background: | Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. |
| Applications: | Western blot; ELISA |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | pH: 8.00; Constituents: 0.31% Glutathione, 0.79% Tris HCl |
| Alternative Names: | dJ138B7.3/H-L(3)MBT/H-l(3)mbt protein |
| Tag: | GST |
| Amino Acid Sequence: | MRRREGHGTDSEMGQGPVRESQSSDPPALQFRISEYKPLNMAGVEQPPTP ELRQEGVTEYEDGGAPAGDGEAGPQQAEDHPQNPPEDPNQDPPEDDSTCQ CQACGPHQAAGPDLGSSNDGCPQLFQERSVIVENSSGSTSASELLKPMKK RKRREYQSPSEEESEPEAMEKQEEGKDPEGQPTASTPESEEWSSSQPATG EKKECWSWESYLEEQKAITAPVSLFQDSQAVTHNKNGFKLGMKLEGIDPQ HPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTG HKLQPPKGYKEEEFSWSQYLRSTRAQAAPKHLFVSQSHSPPPLGFQVGMK LEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPV GWCQKQGKPLTPPQDYPDPDNFCWEKYLEETGASAVPTWAFKVRPPHSFL VNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPD IHPAGWCSKTGHPLQPPLGPREPSSASPGGCPPLSYRSLPHTRTSKYSFH HRKCPTPGCDGSGHVTGKFTAHHCLSGCPLAERNQSRLKAELSDSEASAR KKNLSGFSPRKKPRHHGRIGRPPKYRKIPQEDFQTLTPDVVHQSLFMSAL SAHPDRSLSVCWEQHCKLLPGVAGISASTVAKWTIDEVFGFVQTLTGCED QARLFKDEARIVRVTHVSGKTLVWTVAQLGDLVCSDHLQEGKGILETGVH SLLCSLPTHLLAKLSFASDSQY |
| Sequence Similarities: | Contains 1 C2HC-type zinc finger.Contains 3 MBT repeats.Contains 1 SAM (sterile alpha motif) domain. |
| Expression System: | Wheat germ |
| Protein Length: | Full length protein; 1 to 772 |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0070 | L3MBTL1 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0077 | Recombinant Human L3MBTL1 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0097 | Human L3MBTL2 Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0244 | UNC 1215 | Inquiry |
| BSM-0245 | UNC-669 | Inquiry |
| Related Gene / Proteins | |||
| L3MBTL1 | L3MBTL2 | L3MBTL3 | L3MBTL4 |
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