| Cat.No.: | PE-3291 |
| Product Name: | AF9 YEATS Domain, F59A, Recombinant Human |
| Description: | Recombinant human AF9 (MLLT3, YEATS3, accession P42568, amino acids 1 to 149) containing an N-terminal 6xHis tag, expressed in E. coli. The AF9 protein is part of the super elongation complex and also associates with the histone methyltransferase DOT1L. Translocation of the AF9 gene to the MLL gene, resulting in an MLL/AF9 fusion is the most common chromosomal rearrangement involving MLL in de novo AML. The YEATS domain of AF9 binds strongly to histone H3K9 acetylation and, to a lesser extent, H3K27 and H3K18 acetylation. AF9 YEATS Domain, F59A, contains an Phe to Ala substitution at position 59. |
| Applications: | AF9 YEATS Domain, F59A, Recombinant Human AF9 YEATS Domain, F59A, Recombinant Human is useful for protein binding and screening experiments examining acetylated protein substrates. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Molecular Weight: | 19.6 kDa |
| Species: | Human |
| Formulation: | 50 mM Tris-HCl pH 7.5, 200 mM NaCl, 1mM DTT, 20% glycerol. |
| Tag: | His |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0170 | MI-3 | Inquiry |
| BSM-0187 | OICR-9429 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0172 | Human KMT2C / MLL3 peptide | Inquiry |
| ◆ Research Kits | ||
| EKIT-0285 | MLL1 Complex Chemiluminescent Assay Kit | Inquiry |
| EKIT-0286 | MLL1 SAM-Screener Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| MLH1 | MLL | mll1 | MLL2 |
| MLL3 | MLL4 | MLL5 | MLLT1 |
| MLLT3 | |||
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