Express DNA methylation kit (deep well)


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Cat.No.:  EKIT-0586
Product Name:  Express DNA methylation kit (deep well)
Product Overview:  Fastest method for complete, high-throughput (96-well) bisulfite conversion of DNA for methylation analysis.
Description:  The Express DNA methylation kit (deep well) features high-throughput (96-well) bisulfite treatment and conversion of DNA for methylation analysis. No preparation is necessary when using the Express Conversion Reagent. Simply add this reagent to a DNA sample and let the reaction proceed to completion. DNA denaturation and bisulfite conversion processes are combined with added heat to facilitate rapid denaturation. Desulphonation and clean-up of the converted DNA is performed using a unique 96-well spin-plate. High yield, converted DNA is ideal for PCR, array, bisulfite and next generation sequencing.
Background:  Cytosine methylation is a naturally occurring base modification, in both prokaryotic and eukaryotic organisms. It involves the addition of a methyl group to the fifth carbon position of the cytosine pyrimidine ring via a methyltransferase enzyme. It has been demonstrated that aberrant DNA methylation is a widespread phenomenon in cancer and may be among the earliest changes to occur during oncogenesis. DNA methylation has also been shown to play a central role in gene imprinting, embryonic development, X-chromosome gene silencing, and cell cycle regulation.
Kit Components:  Express conversion reagent, Methylation binding buffer, Methylation wash buffer concentrate, L-Desulphonation reagent, Methylation elution buffer, Express binding plate (deep), Express conversion plates, Collection plates, Elution plates
Warning:  For research use only, not for diagnostic use.

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For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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