Recombinant Human MBD1 Cell Lysate


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Cat.No.:  EL-0001
Product Name:  Recombinant Human MBD1 Cell Lysate
Description:  DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.
Species:  Human
Warning:  For research use only, not for diagnostic or therapeutic use.
Gene ID NCBI:  4152
Official Symbol:  MBD1
Official Full Name:  methyl-CpG binding domain protein 1
Synonyms:  MBD1; methyl-CpG binding domain protein 1; methyl-CpG-binding domain protein 1; CXXC3; PCM1; CXXC-type zinc finger protein 3; protein containing methyl-CpG-binding domain 1; methyl-CpG binding domain protein 1 isoform PCM1; the regulator of fibroblast growth factor 2 (FGF-2) transcription; RFT;
mRNA Refseq:  NM_001204136
Protein Refseq:  NP_001191065
MIM:  156535
UniProt ID:  Q9UIS9
Chromosome Location:  18q21
Function:  DNA binding; metal ion binding; methyl-CpG binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription corepressor activity; zinc ion binding;

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