Recombinant Human DNMT1 protein, His & T7-tagged


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Cat.No.:  PE-0265
Product Name:  Recombinant Human DNMT1 protein, His & T7-tagged
Product Overview:  Recombinant Human DNMT1 aa. (Val1343~Leu1570 (Accession # P26358)) fused with N-terminal His & T7 tag was produced in E. coli cells.
Description:  This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Applications:  SDS-PAGE; WB; ELISA; IP.
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Appearance:  Freeze-dried powder
Molecular Weight:  Predicted Molecular Mass: 29.6kDa
Purity:  >95%
Species:  Human
Tag:  His & T7
Endotoxin:  <1.0EU per 1ug (determined by the LAL method)
Reconstitution:  Reconstitute in sterile PBS, pH7.2-pH7.4.
Expression System:  E. coli
Isoelectric Point:  The isoelectric point is 9.7.
Protein Length:  Val1343~Leu1570 (Accession # P26358)
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name:  DNMT1 DNA methyltransferase 1 [ Homo sapiens (human) ]
Gene ID NCBI:  1786
Official Symbol:  DNMT1
Synonyms:  DNMT1; DNA methyltransferase 1; AIM; DNMT; MCMT; CXXC9; HSN1E; ADCADN; m.HsaI; DNA (cytosine-5)-methyltransferase 1; CXXC-type zinc finger protein 9; DNA (cytosine-5-)-methyltransferase 1; DNA MTase HsaI; DNA methyltransferase HsaI
mRNA Refseq:  NM_001130823.2
Protein Refseq:  NP_001124295.1
UniProt ID:  P26358

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