Recombinant Human DNMT3A, GST-tagged


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  • Gene Information
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Cat.No.:  PE-0266
Product Name:  Recombinant Human DNMT3A, GST-tagged
Product Overview:  Recombinant Human DNMT3a, (a-a 2-913), with N-terminal GST tag expressed in baculovirus . MW= 128 kDa.
Description:  CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Applications:  Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Purity:  >50%.
Species:  Human
Formulation:  25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.
Tag:  GST
Expression System:  Baculovirus
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name:  DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ]
Gene ID NCBI:  1788
Synonyms:  DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNMT3A2; M.HsaIIIA; EC 2.1.1.37; DNA MTase HsaIIIA; DNA methyltransferase HsaIIIA; DNA cytosine methyltransferase 3A2; DNA (cytosine-5)-methyltransferase 3A; Dnmt3a; DNA MTase HsaIIIA
mRNA Refseq:  NM_022552
Protein Refseq:  NP_072046
MIM:  602769
UniProt ID:  Q9Y6K1
Chromosome Location:  2p23
Function:  DNA (cytosine-5-)-methyltransferase activity; DNA binding; metal ion binding; chromatin binding; transferase activity; zinc ion binding

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