Recombinant Human DNMT3A, GST-tagged


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  • Gene Information
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Cat.No.:  PE-0269
Product Name:  Recombinant Human DNMT3A, GST-tagged
Product Overview:  Recombinant full-length human DNMT3A was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description:  DNMT3A: DNA (cytosine-5-)-methyltransferase 3 alpha plays important role in genomic imprinting and X chromosome inactivation and is essential for mammalian development. DNMT3A appears to function as a de novo methyltrabsferase, since it can methylate unmethylated and hemimethylated DNA with equal efficiencies. DNMT3A is required for genome wide de novo methylation and is essential for mammalian development. DNMT3A is critical for maintaining active chromatin states of genes that are essential for development.
Applications:  Methyltransferase Assay
Storage:  Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles.
Molecular Weight:  ~162 kDa
Purity:  >70% by densitometry
Species:  Human
Formulation:  Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Tag:  GST
Activity:  The specific activity of DNMT3A was determined to be 250 pmol /min/mg
Expression System:  Sf9 Insect Cells
Concentrations:  0.1 μg/μl
Warning:  This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Gene Name:  DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ]
Gene ID NCBI:  1788
Synonyms:  DNMT3A; DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA MTase HsaIIIA; DNA cytosine methyltransferase 3A2; DNMT3A2; M.HsaIIIA;
mRNA Refseq:  NM_022552
Protein Refseq:  NP_072046
MIM:  602769
UniProt ID:  Q9Y6K1
Chromosome Location:  2p23
Function:  DNA (cytosine-5-)-methyltransferase activity; DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates; DNA binding; chromatin binding; metal ion binding; methyltransferase activity; protein binding; transferase activity; unmethylated CpG binding;

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