| Cat.No.: | PE-0280 |
| Product Name: | Recombinant Mouse Dnmt3b protein, His & T7-tagged |
| Product Overview: | Recombinant Mouse Dnmt3b aa. (Ile581~Glu859 (Accession # O88509)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description: | This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. |
| Applications: | SDS-PAGE; WB; ELISA; IP. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Freeze-dried powder |
| Molecular Weight: | 28kDa as determined by SDS-PAGE reducing conditions. |
| Purity: | >95% |
| Species: | Mouse |
| Tag: | His & T7 |
| Endotoxin: | <1.0EU per 1ug (determined by the LAL method) |
| Reconstitution: | Reconstitute in sterile ddH2O. |
| Expression System: | E. coli |
| Isoelectric Point: | The isoelectric point is 9.3. |
| Protein Length: | Ile581~Glu859 (Accession # O88509) |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Gene Name: | Dnmt3b DNA methyltransferase 3B [ Mus musculus (house mouse) ] |
| Gene ID NCBI: | 13436 |
| Official Symbol: | Dnmt3b |
| Synonyms: | Dnmt3b; DNA methyltransferase 3B; MmuIIIB; DNA (cytosine-5)-methyltransferase 3B; DNA MTase MmuIIIB; DNA methyltransferase MmuIIIB |
| mRNA Refseq: | NM_001003960.4 |
| Protein Refseq: | NP_001003960.2 |
| UniProt ID: | O88509 |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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