Active GMP Recombinant Human KITLG protein
Cat.No. : | KITLG-435HG |
Product Overview : | GMP Recombinant Human KITLG protein(NP_000890.1)(170 aa), fused with His Tag at the C-terminal, was expressed in HEK293 cell in an animal component free process under cGMP guidelines. |
- Specification
- Gene Information
- Related Products
Source : | HEK293 |
Species : | Human |
Bio-activity : | >=5×10^5 IU/mg |
Molecular Mass : | Recombinant Human KITLG contains 170 aa. It has a predicted MW of 19.3 kDa. |
Protein length : | DNA sequence encoding Human SCF(NP_000890.1) was expressed with His tag at the C-terminal. |
Endotoxin : | <=0.01EU/ug |
Purity : | >=95% by SDS-PAGE and HPLC |
Storage : | The lyophilized preparation can be stored at 4°C for 24 months, and the dissolved liquid can be stored at -20°C for 6-12 months to avoid repeated freezing and thawing |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | KITLG KIT ligand [ Homo sapiens ] |
Official Symbol : | KITLG |
Synonyms : | KITLG; KIT ligand; MGF; kit ligand; familial progressive hyperpigmentation 2; FPH2; Kitl; KL 1; mast cell growth factor; SCF; SF; steel factor; stem cell factor; c-Kit ligand; KL-1; SHEP7; kit-ligand; DKFZp686F2250 |
Gene ID : | 4254 |
mRNA Refseq : | NM_000899 |
Protein Refseq : | NP_000890 |
MIM : | 184745 |
UniProt ID : | P21583 |
Products Types
◆ Recombinant Protein | ||
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Kitl-4378M | Recombinant Mouse Kitl Protein | +Inquiry |
KITLG-39C | Recombinant Chicken KITLG Protein | +Inquiry |
Kitl-1713M | Recombinant Mouse Kitl Protein, His-tagged | +Inquiry |
KITLG-199H | Active Recombinant Human KITLG Protein | +Inquiry |
◆ Lysates | ||
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
KITLG-583MCL | Recombinant Mouse KITLG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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