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Active GMP Recombinant Human TNF Protein

Cat.No. : TNF-01HG
Product Overview : Recombinant human TNF protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Source : CHO-K1
Species : Human
Form : Lyophilized powder
Endotoxin : <20 EU/mg
Bio-activity : >3.0 x 10^7 IU/mg
Purity : >98.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE.
Storage Buffer : 10mM Phosphate-Buffered Saline (pH 7.2)
Storage : Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing.
Sterility : Sterility
Instructions : It is recommended that lyophilized GMP rhTNF be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration.
Gene Name : TNF tumor necrosis factor [ Homo sapiens (human) ]
Official Symbol : TNF
Synonyms : DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
Gene ID : 7124
mRNA Refseq : NM_000594.4
Protein Refseq : NP_000585.2
UniProt ID : P01375
MIM : 191160

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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