INSRb Functional Assay Kit
Cat.No. : | Kit-1606 |
Product Overview : | RTK Functional cell lines are engineered to co-a ProLink (PK) tagged RTK, an Enzyme Acceptor (EA) tagged SH2 domain, and, in some cases, an untagged co-receptor. Activation of the RTK-PK induces receptor dimerization, leading to SH2-EA recruitment, and forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance. |
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Size : | 100 dp(1 x 96-well)/200 dp(2 x 96-well)/1000 dp(10 x 96-well) |
Storage : | Short term (2 weeks): Store in vapor phase of liquid N2 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDistinctive features in the downstream signaling pathways activated by INSRb contribute to the complexity of insulin receptor isoform interactions.
Insulin receptor isoform B (INSRb) serves a pivotal role in cellular processes, particularly in mediating the effects of insulin.
INSRb is predominantly expressed in certain tissues or cell types, influencing its localized impact on insulin signaling.
In glucose metabolism and insulin signaling pathways, INSRb has specific roles distinct from other isoforms, contributing to its functional uniqueness.
Associations between INSRb and specific diseases or metabolic disorders are areas of ongoing research.
INSRb is crucial for insulin sensitivity, playing a vital role in maintaining normal insulin responsiveness.
INSRb differs from other isoforms of the insulin receptor, with specific variations in its structure and functions, particularly compared to isoform A (INSRA).
Customer Reviews (3)
Write a review- Citations of the product in relevant scientific literature validated its significance in groundbreaking research.
- The product's role in contributing to high-impact publications and scientific journals enhanced its credibility.
- The product's compatibility with open science practices positively influenced our decision to adopt it for our experiments.
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