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Active Native Bovine alpha-Thrombin-DFP

Cat.No. : Thrombin-28B
Product Overview : Native Bovine alpha-Thrombin was purified from Plasma. DFP is thrombin blocked with DFP (Diisopropylfluorophosphate).
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Description : Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII. Thrombin has also been reported to activate factor XIII and platelets, and also functions as a vasoconstrictor protein. The procoagulant activity of thrombin is arrested in two ways: 1) inhibition by either heparin cofactor II or the antithrombin III/heparin complex; or 2) complex formation with thrombomodulin. Formation of the thrombin/thrombomodulin complex results in the inability of thrombin to cleave fibrinogen and activate factors V and VIII, but increases the efficiency of thrombin for activation of the anticoagulant, protein C.
Source : Plasma
Species : Bovine
Form : 20 mM Hepes, 150 mM NaCl, pH 7.4
Bio-activity : approximately 3800 NIH units/mg
Molecular Mass : 36700 Da
Purity : >95% by SDS-PAGE
Storage : Glyercol formulation: -20°CHepes formulation: -80°C

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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