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Active Native Bovine Collagen Type V Protein

Cat.No. : Col-01B
Product Overview : Bovine COLLAGEN Type V has been prepared from Bovine Placenta and is chromatographically and immunologically pure.
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  • Gene Information
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Description : In muscle tissue, collagen serves as a major component of the endomysium. Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. This collagen appears to be largely restricted to structures identifiable as basement membranes. In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. The extent to which type VII and VIII collagens are distributed is not known.
Source : Bovine
Species : Bovine
Form : Liquid (sterile filtered). 0.5M Acetic Acid.
Bio-activity : This product reacts with anti-Collagen Type V. Reaction with anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Purity : Bovine COLLAGEN Type V has been prepared from Bovine Placenta and is chromatographically and immunologically pure.
Applications : ELISA: 1:10,000; Western Blot: 1:1000; Immunohistochemistry: 1:100-1:500; Other Dilution: User Optimized. For use as a control or standard in indirect trapping ELISA for quantitation of antigen using a standard curve, for immunoprecipitation and for other immunological assays as optimized by the user. Specific conditions should be optimized by user.
Storage : Store vial at 4 centigrade prior to opening. This product is stable at 4 centigrade as an undiluted liquid. Dilute only prior to immediate use.
Concentration : 1 mg/ml by UV absorbance at 280 nm.
Preservative : 0.01% (w/v) Sodium Azide
Gene Name : COL5A1
Official Symbol : COL5A1
Synonyms : Extracellular Matrix Protein; EDSC; EDSCL1
Gene ID : 100848491
mRNA Refseq : XM_024999726.1
Protein Refseq : XP_024855494.1
UniProt ID : G3MZI7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does the COL5A1 protein contribute to the biomechanical properties of tendons and ligaments? 11/12/2022

The presence of normal COL5A1 protein is essential for maintaining the tensile strength and elasticity of tendons and ligaments.

How can the COL5A1 protein be used as a biomarker for tendon injuries? 09/22/2021

The presence of COL5A1 protein in blood or tissue samples can be indicative of tendon damage, making it a potential biomarker for tendon injuries.

What therapeutic strategies are being explored to target the COL5A1 protein in the treatment of tendon injuries? 06/20/2021

Some researchers are investigating the use of gene therapy or protein replacement therapy to address abnormalities in the production of COL5A1 protein in tendon injuries.

How is the COL5A1 protein relevant in the context of Ehlers-Danlos syndrome (EDS)? 07/07/2017

Mutations in the COL5A1 gene can lead to the production of abnormal type V collagen, resulting in the classical type of EDS characterized by joint hypermobility and skin hyperextensibility.

Can abnormalities in the COL5A1 gene be detected through genetic testing? 03/26/2016

Yes, genetic testing can identify mutations in the COL5A1 gene, providing a means to diagnose conditions such as EDS and other connective tissue disorders.

Customer Reviews (3)

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Reviews
12/02/2018

    The COL5A1 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.

    09/26/2018

      Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.

      04/27/2018

        With the COL5A1 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.

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