"tetX" Related Products

Native Clostridium tetani Tetanus toxin

Cat.No.: tetX-110C
Product Overview: Tetanus toxin from Clostridium tetani has been used to inhibit vesicular release in Pannexin 1-transfected Neuro2A cells1.
Description: Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo.
Source: C. tetani
Species: C. tetani
Bio-activity: Two bands by SDS-PAGE under reducing conditions (100 kDa heavy chain and 50 kDa light chain).
Molecular Mass: 150 kDa (heavy chain (100 kDa) and a light chain (50 kDa) connected through an interchain disulfide bond)
Applications: Each lot of tetanus toxin is tested to confirm binding activity to GT1b ganglioside using the hemagglutination assay of Tayot, et al.
Storage: Store at 2-8 centigrade
Reconstitution: Each vial, when reconstituted with 100μL of sterile purified water, contains 25μg of tetanus toxin in 20 mM HEPES, pH 7.4 with 1.25% lactose.
Gene Name: tetanus toxin tetX [ Clostridium tetani E88 ]
Official Symbol: tetX
Synonyms: tetX; Tetanus toxin
Gene ID: 1061100
Protein Refseq: WP_011100836.1

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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