Native Swine Myelin Basic Protein

• Cat.No.: MBP-99S
• Product Overview: Native Swine MBP was extracted under acidic conditions and further purified by cation chromatography from pig brain. This product is routinely evaluated using active MAP Kinase 3/ERK1.

Specification

• Description: MBP exists as four major forms in the pig CNS with apparent molecular weights of 21.5K, 20.2K, 18.5K, and 17.3K. Native pig MBP is extracted under acidic conditions and further purified by cation chromatography. MBP is an efficient substrate for numerous protein kinases including ERK/MAP Kinase family, cAMP-dependent Protein Kinase, Calmodulin-dependent Protein Kinase, Protein Kinase C, and Phosphorylase Kinase.
• Source: Pig Brain
• Species: Pig
• Molecular Mass: ~21.5 kDa
• Applications: WB
• Tag: Non

Gene Information

• Gene Name: MBP myelin basic protein [ Sus scrofa ]
• Official Symbol: MBP
• Synonyms: myelin basic protein
• Gene ID: 414286
• mRNA Refseq: NM_001001546
• Protein Refseq: NP_001001546
• Chromosome Location: 1; 1 80 cM

Reviews

12/21/2019

Product exactly as described.

07/27/2018

Worked well in ELISA.

05/13/2018

Excellent customer support, helpful.

Q&As

What is the primary function of the MBP gene and its encoded protein?

The MBP gene encodes the Myelin Basic Protein, which is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system.

How is MBP expression regulated during neural development?

MBP expression is tightly regulated during neural development. It increases as oligodendrocytes differentiate and begin to form the myelin sheath around axons.

What role does MBP play in multiple sclerosis (MS)?

In multiple sclerosis (MS), an autoimmune disease, MBP is one of the targets for immune cells. The immune system attacks and degrades the myelin sheath, leading to the characteristic symptoms of MS.

What are the implications of MBP in demyelinating diseases beyond MS?

Other than MS, demyelinating diseases like Pelizaeus-Merzbacher disease and some leukodystrophies can be linked to issues with MBP. These conditions can lead to a range of neurological symptoms due to impaired nerve transmission.

Are there any therapeutic strategies targeting MBP or its pathways in neurodegenerative diseases?

Therapeutic strategies targeting MBP mainly focus on preventing the immune system from attacking it, especially in the context of MS. This includes the development of immunomodulatory drugs and therapies to promote remyelination.

Are there any known diseases or conditions associated with mutations or dysregulation of MBP?

Beyond MS, mutations or dysregulation of MBP can lead to other rare demyelinating diseases and some forms of leukodystrophy.

How does MBP contribute to the structure and function of myelin sheaths in the nervous system?

MBP plays a crucial role in the formation of the myelin sheath, a fatty layer that insulates nerve fibers. It helps compact and stabilize the layers of myelin, ensuring efficient nerve signal transmission.