PDE1B Cell-Based Reporter Assay Kit


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PDE1B Cell-Based Reporter Assay Kit

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Cat.No. : Kit-1826
Product Overview : Phosphodiesterases (PDEs) regulate the intracellular levels of cAMP and cGMP by hydrolyzing cAMP and cGMP to their inactive 5 monophosphates. These cyclic nucleotides play an important role as second messengers in diverse physiological functions. PDE1B plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. PDE1B hydrolyzes both cAMP and cGMP to nucleoside 5-prime monophosphate. Although it prefers cGMP at low substrate levels, it has a Vmax that is approximately equal for both cGMP and cAMP (Polli, J.W. and Koncaid, R.L., 1994; Yu, J. et al., 1997).
Size : 500 reactions
Applications : The PDE1B Cell-Based Reporter Assay Kit is designed for screening inhibitors of PDE1B and for monitoring PDE1B/ cGMP/ Ca2+ channel signaling pathway activity in vivo.
Storage : Store cell line in liquid nitrogen immediately upon receipt. Store other components as recommended. Components are stable at least 12 months from date of receipt, when stored as directed.
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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