BCL2L11
BCL2-like 11 (apoptosis facilitator)
BCL2L11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl2-L-11; Bcl2 interacting mediator of cell death; bcl2-interacting mediator of cell death; Bim; Bod; 1500006F24Rik;
CASP10
caspase 10, apoptosis-related cysteine peptidase
CASP10; caspase 10, apoptosis-related cysteine peptidase; MCH4; ALPS2; FLICE2; caspase-10; CASP-10; FADD-like ICE2; apoptotic protease MCH-4; ICE-like apoptotic protease 4; interleukin-1B-converting enzyme 2; caspase 10, apoptosis-related cysteine protease; FAS-associated death domain protein interleukin-1B-converting enzyme 2;
CASP2
caspase 2, apoptosis-related cysteine peptidase
Apoptosis related cysteine peptidase; CASP 2; Casp 2L Pro; CASP2; Caspase 2 apoptosis related cysteine protease; Caspase2; Developmentally down regulated 2; ICH 1; ICH 1 protease; ICH 1L; ICH 1L/1S; ICH1; ICH1 protease; ICH1L/1S; NEDD 2; NEDD2 apoptosis regulatory gene; Neural precursor cell expressed; Neural precursor cell expressed developmentally down regulated 2; OTTHUMP00000025259; OTTHUMP00000202227; neural precursor cell expressed developmentally down-regulated protein 2; EC 3.4.22.55; Protease ICH-1;
Casp3
caspase 3, apoptosis-related cysteine peptidase
CASP3; caspase 3, apoptosis-related cysteine peptidase; CPP32; SCA-1; CPP32B; Apopain; CPP-32; EC 3.4.22.56; Yama; procaspase3; Cysteine protease CPP32; PARP cleavage protease; SREBP cleavage activity 1; Yama protein; caspase 3, apoptosis-related cysteine protease;
CASP4
caspase 4, apoptosis-related cysteine peptidase
Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP-4; CASP4; CASP4_HUMAN; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; OTTHUMP00000231863; OTTHUMP00000231864; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57; EC 3.4.22;
CASP5
caspase 5, apoptosis-related cysteine peptidase
Apoptosis related cysteine protease; apoptosis-related cysteine protease; CASP5; ICE(rel)III; ICERELIII; ICH 3; ICH 3 protease; ICH3; TY; TY Protease; caspase-5; CASP-5; OTTHUMP00000045729; OTTHUMP00000209889; OTTHUMP00000231914; OTTHUMP00000231915; caspase 5, apoptosis-related cysteine peptidase; MGC141966; EC 3.4.22.58; EC 3.4.22;
CASP6
caspase 6, apoptosis-related cysteine peptidase
CASP6; caspase 6, apoptosis-related cysteine peptidase; MCH2; caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease;
CASP7
caspase 7, apoptosis-related cysteine peptidase
CASP7; Apoptotic protease Mch3; CASP 7; Caspase 7 subunit p11; Caspase 7 subunit p20; CMH1; ICE LAP3; ICE like apoptotic protease 3; OTTHUMP00000020510; OTTHUMP00000020511; OTTHUMP00000020512; OTTHUMP00000020513; OTTHUMP00000020514; Lice2 alpha/beta/gamma; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine protease; caspase 7, apoptosis-related cysteine peptidase; MCH3; CMH-1; ICE-LAP3; EC 3.4.22.60; EC 3.4.22;
CASP8
caspase 8, apoptosis-related cysteine peptidase
CASP8; caspase 8, apoptosis-related cysteine peptidase; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; caspase-8; FADD-like ICE; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease;
CASP9
caspase 9, apoptosis-related cysteine peptidase
CASP9; caspase 9, apoptosis-related cysteine peptidase; MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; caspase-9; apoptotic protease MCH-6; ICE-like apoptotic protease 6; apoptotic protease activating factor 3; protein phosphatase 1, regulatory subunit 56;
XIAP
X-linked inhibitor of apoptosis
XIAP; X-linked inhibitor of apoptosis; API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3; E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4;
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
AIFM1; apoptosis-inducing factor, mitochondrion-associated, 1; PDCD8, programmed cell death 8 (apoptosis inducing factor); apoptosis-inducing factor 1, mitochondrial; AIF; striatal apoptosis-inducing factor; programmed cell death 8 (apoptosis-inducing factor); PDCD8; COXPD6; MGC111425;
CFLAR
CASP8 and FADD-like apoptosis regulator
CFLAR; CASP8 and FADD-like apoptosis regulator; CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1; usurpin beta; caspase homolog; inhibitor of FLICE; caspase-eight-related protein; MACH-related inducer of toxicity; FADD-like anti-apoptotic molecule; FADD-like antiapoptotic molecule 1; caspase-related inducer of apoptosis; cellular FLICE-like inhibitory protein; caspase-like apoptosis regulatory protein;
AATF
apoptosis antagonizing transcription factor
AATF; apoptosis antagonizing transcription factor; protein AATF; CHE 1; CHE1; DED; rb-binding protein Che-1; apoptosis-antagonizing transcription factor; CHE-1;
API5
apoptosis inhibitor 5
API5; apoptosis inhibitor 5; AAC 11; AAC11; API5 like 1; API5L1; fibroblast growth factor 2 interacting factor 2; migration inducing protein MIG8; FIF; antiapoptosis clone 11 protein; migration-inducing protein MIG8; cell migration-inducing gene 8 protein;
AVEN
apoptosis, caspase activation inhibitor
AVEN; apoptosis, caspase activation inhibitor; PDCD12; cell death regulator aven; programmed cell death 12; OTTHUMP00000159733;
BFAR
bifunctional apoptosis regulator
BFAR; bifunctional apoptosis regulator; BAR; RNF47; RING finger protein 47; bifunctional apoptosis inhibitor;
CASP14
caspase 14, apoptosis-related cysteine peptidase
CASP14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis related cysteine protease; caspase-14; apoptosis related cysteine protease; MGC119078; MGC119079; MICE; CASP-14; apoptosis-related cysteine protease; caspase 14, apoptosis-rel;
CIAPIN1
cytokine induced apoptosis inhibitor 1
CIAPIN1; cytokine induced apoptosis inhibitor 1; anamorsin; 2810413N20Rik; CIAPIN 1; DRE2; Predicted protein of HQ0915; PRO0915; OTTHUMP00000164661; cytokine-induced apoptosis inhibitor 1; fe-S cluster assembly protein DRE2 homolog;
MOAP1
modulator of apoptosis 1
MOAP1; modulator of apoptosis 1; MAP 1; paraneoplastic Ma antigen family member 4; PNMA4; MAP1; paraneoplastic antigen Ma4; paraneoplastic antigen like 4; MAP-1;
PAWR
PRKC, apoptosis, WT1, regulator
PAWR; PRKC, apoptosis, WT1, regulator; PRKC apoptosis WT1 regulator protein; par 4; PAR4; WT1-interacting protein; transcriptional repressor PAR4; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response pr;
THAP1
THAP domain containing, apoptosis associated protein 1
THAP1; THAP domain containing, apoptosis associated protein 1; dystonia 6, torsion (autosomal dominant) , DYT6; 4833431A01Rik; FLJ10477;
AATK
apoptosis-associated tyrosine kinase
AATK; apoptosis-associated tyrosine kinase; serine/threonine-protein kinase LMTK1; AATYK; AATYK1; KIAA0641; lemur tyrosine kinase 1; LMR1; LMTK1; p35-binding protein; CDK5-binding protein; brain apoptosis-associated tyrosine kinase; p35BP;
AIFM2
apoptosis-inducing factor, mitochondrion-associated, 2
AIFM2; apoptosis-inducing factor, mitochondrion-associated, 2; AMID, apoptosis inducing factor (AIF) like mitochondrion associated inducer of death; apoptosis-inducing factor 2; FLJ14497; PRG3; 5430437E11Rik; AIFM2_HUMAN; AMID; Apoptosis inducing factor (AIF) homologous mitochondrion associated inducer of death; Apoptosis inducing factor (AIF) like mitochondrion associated inducer of death; Apoptosis inducing factor mitochondrion associated 2; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; Cys51Stop; HGNC11998; p53 responsive gene 3; p53 tumor suppressor; p53-responsive gene 3 protein; TRP53; Tumor protein p53; OTTHUMP00000019739; OTTHUMP00000019740; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of d; RP11-367H5.2;
BCL2L10
BCL2-like 10 (apoptosis facilitator)
BCL2L10; BCL2-like 10 (apoptosis facilitator); bcl-2-like protein 10; BCL B; Boo; Diva; bcl2-L-10; apoptosis regulator Bcl-B; anti-apoptotic protein NrH; BCL-B; MGC129810; MGC129811;
BCL2L13
BCL2-like 13 (apoptosis facilitator)
BCL2L13; BCL2-like 13 (apoptosis facilitator); bcl-2-like protein 13; BCL RAMBO; MIL1; Protein Mil1; BCL-RAMBO; Bcl2-L-13;
BCL2L14
BCL2-like 14 (apoptosis facilitator)
BCL2L14; BCL2-like 14 (apoptosis facilitator); apoptosis facilitator Bcl-2-like protein 14; BCL G; BCLG; bcl2-L-14; apoptosis regulator BCL-G;
BIK
BCL2-interacting killer (apoptosis-inducing)
BIK; BCL2-interacting killer (apoptosis-inducing); bcl-2-interacting killer; NBK; apoptosis inducer NBK; apoptosis-inducing NBK; BP4; BIP1;
SYVN1
synovial apoptosis inhibitor 1, synoviolin
SYVN1; synovial apoptosis inhibitor 1, synoviolin; E3 ubiquitin-protein ligase synoviolin; HRD1; KIAA1810; MGC40372;
CCAR1
cell division cycle and apoptosis regulator 1
CCAR1; cell division cycle and apoptosis regulator 1; cell division cycle and apoptosis regulator protein 1; CARP 1; CARP1; FLJ10590; death inducer with SAP domain; cell cycle and apoptosis regulatory protein 1; MGC44628; RP11-437A18.1;
NAIP
NLR family, apoptosis inhibitory protein
NAIP; NLR family, apoptosis inhibitory protein; baculoviral IAP repeat containing 1 , BIRC1; baculoviral IAP repeat-containing protein 1; NLR family; BIR domain containing 1; NLRB1; nucleotide binding oligomerization domain; leucine rich repeat and BIR domain containing 1; neuronal apoptosis inhibitory protein; psi neuronal apoptosis inhibitory protein; nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1; BIRC1; psiNAIP; FLJ18088; FLJ42520; FLJ58811;
NOL3
nucleolar protein 3 (apoptosis repressor with CARD domain)
NOL3; nucleolar protein 3 (apoptosis repressor with CARD domain); ARC; FCM; MYP; NOP; NOP30; nucleolar protein 3; nucleolar protein of 30 kDa; muscle-enriched cytoplasmic protein;
PERP
PERP, TP53 apoptosis effector
PERP; PERP, TP53 apoptosis effector; p53 apoptosis effector related to PMP-22; dJ496H19.1; KCP1; KRTCAP1; PIGPC1; THW; KCP-1; 1110017A08Rik; transmembrane protein THW; p53-induced protein PIGPC1; keratinocyte-associated protein 1; keratinocytes associated;
AEN
apoptosis enhancing nuclease
AEN; apoptosis enhancing nuclease; interferon stimulated exonuclease gene 20kDa like 1 , ISG20L1; apoptosis-enhancing nuclease; FLJ12484; FLJ12562; AEN_HUMAN; Interferon stimulated exonuclease gene 20kDa like 1; Interferon stimulated exonuclease gene 20kDa like 1, isoform CRA_a; Interferon-stimulated 20 kDa exonuclease-like 1; ISG20L1; pp12744; interferon stimulated exonuclease gene 20kDa-like 1;
TP53AIP1
tumor protein p53 regulated apoptosis inducing protein 1
TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1; p53-regulated apoptosis-inducing protein 1; p53AIP1;
SIVA1
SIVA1, apoptosis-inducing factor
SIVA1; SIVA1, apoptosis-inducing factor; apoptosis regulatory protein Siva; CD27BP; SIVA; Siva 1; Siva 2; CD27 binding (Siva) protein; CD27-binding (Siva) protein; Siva-1; Siva-2;
THAP3
THAP domain containing, apoptosis associated protein 3
THAP3; THAP domain containing, apoptosis associated protein 3; THAP domain-containing protein 3; 2010013E08Rik; snoRNA MBI 15; 2210418H06Rik; MGC33488; OTTMUSP00000011101; RGD1308109; RP23-460D14.4;
AIFM3
apoptosis-inducing factor, mitochondrion-associated, 3
AIFM3; apoptosis-inducing factor, mitochondrion-associated, 3; apoptosis-inducing factor 3; AIFL; FLJ30473; apoptosis-inducing factor like; FLJ45137;
THAP2
THAP domain containing, apoptosis associated protein 2
THAP2;THAP domain containing, apoptosis associated protein 2;20854;ENSG00000173451;12q21.1;DKFZp564I0422;THAP domain-containing protein 2;THAP domain-containing protein 2;
CAAP1
caspase activity and apoptosis inhibitor 1
CAAP1;caspase activity and apoptosis inhibitor 1;C9orf82, chromosome 9 open reading frame 82;conserved anti-apoptotic protein;CAAP;conserved anti apoptotic protein;FLJ13657;C9orf82;RP11-337A23.1;
Mitochondrial Control of Apoptosis
Apoptosis is a highly regulated programmed cell death (PCD), it is vital to the development and homeostasis of multicellular organisms. Among various organelles, mitochondria play a central role in the regulation of apoptotic cell death. Under a certain death stimuli, different apoptogenic facto...
Apoptosis Signal Pathway Overview
Fig1. Apoptosis Signal Pathway Overview Apoptosis is a kind of programmed cell death (PCD) plays a fundamental role in multicellular organism development and tissue homeostasis. We might take it as a regulated cellular suicide mechanism. Abnormal regulation of this process is associated with a wi...
