Recombinant Active Human CXCL1 Protein, His-tagged(N-ter)
|Product Overview :||Recombinant Active Human CXCL1 Protein with His tag (N-ter) was expressed in E. coli.|
- Gene Information
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|Description :||This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]|
|Source :||E. coli|
|Bio-activity :||Determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CXCR2. The ED50 for this effect is < 3 ng/mL.|
|AA Sequence :||ASVATELRCQCLQTLQGIHPKNIQS VNVKSPGPHCAQTEVIATLKNGRKA CLNPASPIVKKIIEKMLNSDKSN|
|Endotoxin :||Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.|
|Purity :||> 98% (by SDS-PAGE)|
|Notes :||For laboratory research only, not for drug, diagnostic or other use.|
|Storage :||Lyophilized protein should be stored at -20°C. After reconstitution, aliquot and store at -20°C or -80°C for up to one month. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening.|
|Storage Buffer :||PBS (pH 7.4)|
|Reconstitution :||It is recommended to reconstitute the lyophilized protein in sterile water to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min at room temperature to make sure the protein is dissolved completely.|
|Gene Name :||CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens ]|
|Official Symbol :||CXCL1|
|Synonyms :||CXCL1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein , FSP, GRO1, GRO1 oncogene (melanoma growth stimulating activity, alpha) , MGSA; growth-regulated alpha protein; GROa; MGSA a; NAP 3; SCYB1; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha); FSP; GRO1; MGSA; NAP-3; MGSA-a;|
|Gene ID :||2919|
|mRNA Refseq :||NM_001511|
|Protein Refseq :||NP_001502|
|UniProt ID :||P09341|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (7)Ask a question
Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.
It mediates inflammation by promoting leukocyte migration and activation.
In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.
CXCL1 contributes to angiogenesis, supporting new blood vessel formation.
CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.
CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.
CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.
Customer Reviews (3)Write a review
Efficient delivery, great service. -
Product as described, perfect. -
Reliable for protein work. -
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